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abcuro
abcuro
AdvanCell Isotopes
AdvanCell Isotopes
Aetion
Aetion
Aliada Therapeutics
Aliada Therapeutics
Atalanta Therapeutics
Atalanta Therapeutics
Attovia Therapeutics
Attovia Therapeutics
Avilar Therapeutics
Avilar
Bluebird Bio
Bluebird Bio
Carbon Health
Carbon Health
Click Therapeutics
Click Therapeutics
Common Sensing
Common Sensing
Curevo Vaccine
Curevo
Curisium
Curisium
Eligo Bioscience
Eligo
Empatica
Empatica
Escient Pharmaceuticals
Escient Pharmaceuticals
Evidation
Evidation
Expansion Therapeutics
Expansion Therapeutics
Fate Therapeutics
Fate Therapeutics
Fulcrum Therapeutics
Fulcrum Therapeutics
GlycoMimetics
GlycoMimetics
Glycomine
Glycomine
Granite Bio
Granite Bio
i2O Therapeutics
i2O Therapeutics
Icosavax
Icosavax
Imbria Pharmaceuticals
Imbria Pharmaceuticals
Immune Design
Immune Design
Inozyme Pharma
Inozyme Pharma
KaloBios
KaloBios
Kymera Therapeutics
Kymera Therapeutics
Latigo Bio
Latigo
LAVA Therapeutics
LAVA Therapeutics
Lumena Pharmaceuticals
Lumena Pharmaceuticals
Lysosomal Therapeutics
Lysosomal Therapeutics
MacroGenics
MacroGenics
Matchpoint Therapeutics
Matchpoint Therapeutics
Medisafe
Medisafe
Minervax
Minervax
Mirador Therapeutics
Mirador Therapeutics
Muna Therapeutics
Muna Therapeutics
Navitor
Navitor
NextPoint Therapeutics
NextPoint Therapeutics
NodThera
NodThera
Normunity
Normunity
Nucleai
nucleai
Nura Bio
Nura Bio
Nuvig Therapeutics
Nuvig Therapeutics
Odyssey Therapeutics
Odyssey Therapeutics
Omada Health
Omada Health
OMass Therapeutics
OMass
Ovid Therapeutics
Ovid Therapeutics
Proteostasis Therapeutics
Proteostasis Therapeutics
Q32 Bio
Q32 Bio
QurAlis
QurAlis
ReCode Therapeutics
ReCode
Rome Therapeutics
Rome Therapeutics
Science37
Science37
Selecta Biosciences
Selecta Biosciences
Sudo Biosciences
Subo Biosciences
T-Therapeutics
T-Therapeutics
Therini Bio
Therini Bio
Tisento Therapeutics
Tisento Therapeutics
Ultragenyx
Ultragenyx
Unum Therapeutics
Unum Therapeutics
Veralox Therapeutics Inc
Veralox Therapeutics Inc
Voluntis
Voluntis
Yumanity Therapeutics
Yumanity Therapeutics
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abcuro
Private
Newton, MA
www.abcuro.com
Developing treatments for autoimmune and cancer indications.

Abcuro is a biotechnology company developing treatments for autoimmune and cancer indications modulated by cytotoxic T and NK cells that express the inhibitory immune checkpoint receptor KLRG1 (killer cell lectin-like receptor G1). The company is advancing ABC008 toward the clinic, a first-in-class anti-KLRG1 antibody designed to deplete cytotoxic T cells that attack healthy muscle tissue in patients with inclusion body myositis (IBM). The company is also advancing ABC015, an anti-KLRG1 blocking antibody capable of reactivating inhibited cytotoxic T and NK cells in the tumor microenvironment.

Press releases

Abcuro Announces $200 Million Series C Financing to Advance Its First-In-Class Medicine in Development for Inclusion Body Myositis
Feb 12, 2025
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Abcuro Announces $155 Million Oversubscribed Series B Financing to Further Advance Autoimmune Pipeline
Aug 17, 2023
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Abcuro Initiates Phase 1/2 Trial Evaluating ABC008 in Patients with T Cell Large Granular Lymphocytic Leukemia
Oct 04, 2022
Read More
Abcuro Appoints Alex Martin as Chief Executive Officer
Oct 04, 2022
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AdvanCell Isotopes
Private
Brisbane, Australia
www.advancell.com.au
212Pb radiotherapeutics company with leading isotope manufacturing capability.

AdvanCell is is advancing a first-in-isotope 212Pb PSMA targeting radioligand therapeutic for prostate cancer alongside a pipeline of radiotherapeutic programs supported by a leading 212Pb manufacturing capability.

Press releases

AdvanCell Enters Into Strategic Collaboration with Lilly to Advance Novel Targeted Alpha Therapies for the Treatment of Cancer
Feb 10, 2025
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AdvanCell Successfully Completes an Oversubscribed US$112M Series C Financing
Feb 03, 2025
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Aetion
Private
New York City, NY
aetion.com
Delivering real-world evidence for life sciences, payers, providers, and regulator agencies.

Aetion is a health care technology company that delivers real-world evidence for life sciences, payers, providers, and regulator agencies.

Founded by Harvard Medical School faculty members with decades of experience in epidemiology and health outcomes research, Aetion informs health care’s most critical decisions — what works best, for whom, and when — to guide treatment development, commercialization, and payment innovation into health care’s modern era.

Press releases

RCT-DUPLICATE Findings Demonstrate Capability of Real-World Evidence Studies to Reach Conclusions Similar to Randomized Clinical Trials
Apr 25, 2023
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Aetion acquires synthetic data trailblazer Replica Analytics
Jan 04, 2022
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FDA selects Aetion Evidence Platform® to advance regulatory science and innovation
Oct 21, 2021
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Aetion Closes $110M Series C Funding Round Led by Warburg Pincus
May 11, 2021
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Sanofi and Aetion launch enterprise-wide collaboration to advance regulatory submissions using real-world evidence
Nov 20, 2019
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Global Health Care Leaders Back Aetion with $27 Million Strategic Investment
Feb 05, 2019
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Aliada Therapeutics
Private
Boston, MA
www.aliadatx.com
Harnessing innate mechanisms to transport diverse large-molecule cargoes across the blood-brain barrier.

Aliada Therapeutics is a biotechnology company working to overcome delivery hurdles in CNS drug development. Aliada is advancing a new generation of CNS therapeutics using its novel BBB-crossing Modular Delivery (MODEL) platform technology, which has been shown to efficiently transport a diverse array of therapeutic cargoes into the brain, resulting in enhanced downstream effectiveness and addressing the critical need for efficient and versatile delivery technologies for large molecules and oligonucleotides. The company was co-founded by RA Capital Management, Raven, Johnson & Johnson, and Johnson & Johnson Innovation - JJDC, with further investment from OrbiMed and Sanofi Ventures. 

Press releases

AbbVie Completes Acquisition of Aliada Therapeutics
Dec 13, 2024
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AbbVie to Acquire Aliada Therapeutics, Strengthening Focus in Alzheimer’s Disease and Neuroscience Pipeline
Oct 28, 2024
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Chiesi Global Rare Diseases Announces Co-Development Agreement with Aliada Therapeutics to Advance Blood-Brain Barrier-Crossing Platform Technology in Lysosomal Storage Disorders
Aug 15, 2023
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Atalanta Therapeutics
Private
Boston, MA
www.atalantatx.com
Advancing best-in-class siRNA therapeutics for CNS disease.

Atalanta Therapeutics is developing a next-generation RNAi platform leveraging divalent small interfering RNA (di-siRNA) for selective gene silencing throughout the brain and spinal cord for diseases of the central nervous system.

Press releases

Atalanta Therapeutics Closes Oversubscribed $97 Million Series B Financing to Advance Two RNAi Therapies for CNS Diseases to Clinical Trials
Jan 28, 2025
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Attovia Therapeutics
Private
San Carlos, CA
Leveraging a proprietary platform to generate first-in-class and best-in-class bispecifics and multispecifics for the treatment of immune-mediated diseases.

Attovia is building a pipeline of biotherapeutics for the treatment of immune-mediated diseases. The company leverages ATTOBODY, its proprietary biologics platform, to generate first-in-class and best-in-class bispecifics and multispecifics with enhanced potency and tunable half-life.

Press releases

Attovia Therapeutics Announces $90 Million Series C Financing to Advance ATTOBODY-based Programs through Clinical Proof of Concept
Apr 14, 2025
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Avilar
Private
Waltham, MA.
www.avilar-tx.com
Avilar Therapeutics is a biopharmaceutical company pioneering the discovery and development of extracellular protein degraders.

Avilar Therapeutics is a biopharmaceutical company pioneering the discovery and development of extracellular protein degraders. Avilar develops ATACs (ASGPR Targeting Chimeras), a new class of protein degraders that shuttle disease-causing proteins from circulation to the endolysosome where the unwanted proteins are degraded.

Press releases

Avilar Therapeutics Increases Financing to $75 Million to Advance Pipeline of Novel Extracellular Protein Degraders
Feb 16, 2023
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Bluebird Bio
Public
www.bluebirdbio.com
Developing innovative gene therapies for severe genetic and orphan diseases.

At the heart of bluebird bio's product creation efforts is its broadly applicable gene therapy platform for the development of novel treatments for diseases with few or no clinical options. The company's novel approach uses stem cells harvested from the patient's bone marrow into which a healthy version of the disease causing gene is inserted.

After being grown in culture, those cells are given back to the patient. bluebird bio's approach represents a true paradigm shift in the treatment of severe genetic diseases by eliminating the potential complications associated with donor cell transplantation and potentially presenting a one-time transformative therapy. Bluebird bio has two later stage clinical products in development for childhood cerebral adrenoleukodystrophy (CCALD) and beta-thalassemia/sickle cell anemia. The company is also applying its gene therapy platform to oncology through the development of chimeric antigen receptor T-cells in collaboration with Baylor University and Celgene.

Press releases

bluebird bio Announces Closing of Initial Public Offering and Exercise of Over-­‐Allotment Option
Jun 24, 2013
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bluebird bio Announces First Patient Transplanted in Phase 1/2 HGB-205 Study for the Treatment of Beta-Thalassemia and Sickle Cell Anemia
Feb 12, 2013
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Carbon Health
Private
San Francisco, CA
www.carbonhealth.com
Carbon Health is a vertically integrated healthcare provider redefining the care delivery experience to be modern, hybrid, and accessible.

Carbon Health is a modern health provider that is making high-quality healthcare more accessible to everyone. By combining advanced technology with expert care, they simplify access to a full spectrum of health needs – from acute issues to primary care, chronic conditions, as well as clinical research.

Carbon Health has built a full-stack technology platform that enables their patients to completely customize and optimize healthcare delivery to meet their needs. Their technology allows them to operate more efficiently than legacy health providers, effectively lowering the cost of care.

Carbon Health is removing traditional boundaries to make high-quality, transparent, and personal care accessible and affordable.

Click Therapeutics
Private
New York City, NY
clicktherapeutics.com
Developing software as prescription medical treatments for people with unmet medical needs.

Click Therapeutics, Inc. develops and commercializes software as prescription medical treatments for people with unmet medical needs. Through cognitive and neurobehavioral mechanisms, Click’s Digital Therapeutics™ enable change within individuals, and are designed to be used independently or in conjunction with biomedical treatments. The Clickometrics® adaptive data science platform continuously personalizes user experience to optimize engagement and outcomes. Following a groundbreaking clinical trial, Click’s industry-leading smoking cessation program is available nationwide through a wide variety of payers, providers, and employers. Click’s lead prescription program is entering into a multi-center, randomized, controlled, parallel-group, phase III FDA registration trial for the treatment of Major Depressive Disorder in adults.

Press releases

Click Therapeutics Announces FDA Marketing Authorization for CT-132, the First Prescription Digital Therapeutic for the Preventive Treatment of Episodic Migraine in the United States
Apr 15, 2025
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Dassault Systèmes Intensifies the MEDIDATA Commitment to Patient Experience with Investment in Click Therapeutics for Digital Therapeutics beyond Clinical Trials
Mar 19, 2025
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CT-152 (Rejoyn™) is FDA Cleared!
Apr 01, 2024
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Click Therapeutics Announces Collaboration with Indivior to Develop and Commercialize Novel Prescription Digital Therapeutics in Substance Use Disorders
Sep 07, 2023
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Click Therapeutics Initiates Fully Remote Pivotal Trial Using Investigational Prescription Digital Therapeutics to Treat Episodic Migraine
Apr 25, 2023
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Boehringer Ingelheim and Click Therapeutics expand their existing Collaboration to develop Prescription Digital Therapeutics for Schizophrenia
Dec 19, 2022
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Click Therapeutics Receives FDA Breakthrough Device Designation for Prescription Digital Therapeutic to Treat Episodic Migraine
Dec 16, 2022
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Click Therapeutics Completes $52 Million Series B Financing Co-Led by H.I.G. BioHealth Partners and Accelmed Partners
Oct 22, 2021
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Click Therapeutics Expands its Leadership with Executive and Board Appointments
Apr 07, 2021
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Otsuka and Click Therapeutics Initiate First-of-its-Kind Fully Remote Clinical Trial Using Digital Therapeutics as Adjunctive Therapy in Adults With Major Depressive Disorder.
Feb 24, 2021
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Click Therapeutics Announces Appointment of Top Ranked Healthcare Research Analyst Ross J. Muken as Chief Financial Officer
Sep 04, 2019
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OTSUKA AND CLICK THERAPEUTICS COLLABORATE TO DEVELOP AND COMMERCIALIZE DIGITAL THERAPEUTICS FOR PATIENTS WITH MAJOR DEPRESSIVE DISORDER
Jan 03, 2019
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Sanofi Ventures Leads $17 Million Financing of Click Therapeutics
Jul 23, 2018
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Common Sensing
Acquired
Cambridge, MA
www.common-sensing.com
Introducing GoCap, a safer and more convenient way for diabetics to track and dose insulin.

Common Sensing is introducing GoCap, a safer and more convenient way for diabetics to track and dose insulin. GoCap empowers patients by reducing the burden of manual logging, while providing helpful safety alerts and reminders. The aim is to connect patients, family, and care providers with better information feedback. By improving care engagement and motivation, GoCap holds the potential to improve quality of life for diabetics and reduce cost burdens for the health care system.

Press releases

Bigfoot Biomedical Acquires Assets of Common Sensing, Injectable Medicine Device Company and Creator of the Gocap System
Jun 15, 2021
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Curevo
Private
Bothell, WA
www.curevovaccine.com
Best-in-class shingles vaccine with improved tolerability

Curevo is a clinical stage company advancing a non-mRNA adjuvanted subunit vaccine for shingles with improved tolerability.

Press releases

Curevo Raises $110 Million to Advance Amezosvatein Shingles Vaccine
Mar 17, 2025
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Curisium
Acquired
www.curisium.com
Providing scalable innovative contracting solutions with a blockchain-based platform.

Curisium is a healthcare technology and services company that provides scalable innovative contracting solutions with its blockchain-based platform.

The Curisium platform uses cutting-edge blockchain and secure computation technologies to allow payers, providers, and life science companies to efficiently and securely engage in innovative, patient-centric value-based contracts.

Press releases

HealthVerity Acquires Curisium to Enhance Data Exchange for Drug Rebate Processing and Contract Management
Jul 20, 2020
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Curisium Raises $3.5M to Scale Innovative Healthcare Contracting on Blockchain
Dec 14, 2017
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Eligo
Private
Paris
www.eligo.bio
Eligobiotics are a first-in-class proprietary modality that enables the delivery and expression of therapeutic DNA in target bacterial populations of the microbiome.

By focusing on the in-vivo delivery of genetic cargoes to the microbiome, Eligo’s technology goes beyond traditional gene therapy and gene editing, expanding the range of addressable genetic targets. Through precise genetic modification within the human microbiome, this unique approach holds the promise of radically altering the course of numerous chronic and life-threatening diseases that are either triggered or driven by the expression of bacterial genes. 

Press releases

Eligo Bioscience Awarded $5 Million to Advance Breakthrough Genetic Medicine Platform for Immuno-Dermatology
May 19, 2025
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Eligo welcomes genetic medicines leader Bobby Gaspar as chair of its board of directors
Oct 01, 2024
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Eligo Bioscience's Major Advance in Microbial Gene Editing Published in Nature
Jul 11, 2024
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Eligo Bioscience Raises $30 Million To Write a Novel Chapter for Genetic Medicines
Dec 05, 2023
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Empatica
Private
Cambridge, MA
www.empatica.com
Developing medical-grade patient monitoring systems for continuous data collection in real-world multisite trials

Empatica has developed a versatile smartwatch and sensor platform that allows for medical-grade continuous health monitoring.

Empatica's EmbracePlus wearable device is equipped with advanced sensors that allow for the remote collection of physiological data, giving researchers access to a vast range of raw sensor data and clinically validated digital biomarkers.

Their sophisticated full-stack research suite allows to seamlessly conduct clinical research in real-world settings, helping to develop new digital endpoints and digital biomarkers.

Press releases

Empatica Reveals Next Generation FDA-Cleared Epilepsy Watch and Launches AI Seizure Forecasting Study
Feb 28, 2024
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Empatica's Platform Receives New FDA Clearance for Cardiac Digital Biomarkers
Nov 02, 2023
Read More
Empatica Unveils Actigraphy Offering for Clinical Trials at AAN 2023
Apr 24, 2023
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Empatica receives new FDA clearance for its Health Monitoring Platform and announces Series B financing
Nov 22, 2022
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Escient Pharmaceuticals
Acquired
San Diego, CA
www.escientpharma.com
Advancing first-in-class G Protein-Coupled Receptor (GPCR)-targeted drugs.

Escient Pharmaceuticals is a biotechnology company that is advancing first-in-class G Protein-Coupled Receptor (GPCR)-targeted drugs to address serious, unserved medical needs across a broad range of therapeutic indications. Focused on unleashing the therapeutic potential of specific orphan GPCRs, including the novel family of Mas-Related G-Protein Receptors (MRGPRs), Escient’s lead program targets MRGPRX4 for cholestatic and uremic pruritus. Based in San Diego, Calif., Escient is led by an experienced team of biotechnology entrepreneurs with specific expertise in GPCR drug discovery and development.

Press releases

Incyte Announces Acquisition Of Escient Pharmaceuticals And Its Pipeline Of First-In-Class Oral MRGPR Antagonists
Apr 25, 2024
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Escient Pharmaceuticals Announces $120 Million Series C Financing
Nov 28, 2022
Read More
Escient Pharmaceuticals Appoints Joshua Grass, MBA As CEO
Jan 05, 2022
Read More
Escient Pharmaceuticals Raises $77.5 Million Series B Round and Initiates a Phase 1/1b Clinical Trial of EP547, a MRGPR-targeted Therapy to Treat Cholestatic and Uremic Pruritis
Sep 14, 2020
Read More
Evidation
Private
San Mateo, CA
www.evidation.com
Capturing and analyzing passive, continuous behavior data.

Rooted in rigorous science, Evidation captures and analyzes passive, continuous behavior data to quantify health outcomes that more accurately reflect an individual's day-to-day experience.

Press releases

Evidation Extends Collaboration with Sanofi to Develop and Apply Real-World Evidence
Jan 10, 2022
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Evidation Raises $153M to Scale Virtual Health Capabilities of Achievement™ Platform.
Mar 25, 2021
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Evidation Raises $45 Million Series D, Hires CCO To Accelerate Commercial Momentum and Expand Into Virtual Health
Jul 01, 2020
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Evidation Health and BARDA Partner on Early Warning System for COVID-19
Jun 04, 2020
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Evidation Health Secures Financing from Sanofi-Genzyme BioVentures to Fuel Commercial Growth
Oct 10, 2018
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Evidation Health, Tidepool partner to use the Data Generated Every Day by people with Diabetes to improve Clinical Research
Aug 23, 2018
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Evidation Health Announces $30M in New Funding
Aug 01, 2018
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Expansion Therapeutics
Private
Boston, MA
www.expansionrx.com
Pursuing the vast potential of small molecule medicines for RNA-mediated diseases.

Expansion Therapeutics is a drug discovery and development company pursuing the vast potential of small molecule medicines for RNA-mediated diseases. Based on exclusive worldwide rights to groundbreaking research from the laboratory of Matthew D. Disney, Ph.D., at The Scripps Research Institute, Expansion has assembled the intellectual property, know-how, and proprietary enabling technologies and tools necessary to facilitate the creation of potent and specific small molecule binders of RNA. Through this unique platform, Expansion is building a portfolio of novel RNA-targeted drug candidates with activity across a broad number of disease indications. The company’s initial development focus is on therapies for patients with expansion repeat diseases who currently have limited and unsatisfactory treatment options. Expansion is based in San Diego, California and Jupiter, Florida.

Press releases

Expansion Therapeutics Raises $80 Million Series B Financing to Treat Neurodegenerative Diseases
Sep 29, 2021
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Expansion Therapeutics Raises $55.3 Million in Series A Financing to Advance Portfolio of Novel RNA Targeted Small Molecule Medicines to Treat Rare Diseases
Jan 03, 2018
Read More
Fate Therapeutics
Public
www.fatetherapeutics.com
Pioneering a revolutionary approach to cell therapy using renewable master induced pluripotent stem cell (iPSC) lines.

The Company’s first-in-class cell therapy products undergoing clinical development today utilize healthy donor cells, which are modified ex vivo using pharmacologic modulators, such as small molecules, to improve the cells’ biological properties and therapeutic function. The company is pioneering a revolutionary approach to cell therapy using renewable master induced pluripotent stem cell (iPSC) lines generated from a proprietary iPSC product platform to derive cell therapy products that can be delivered off-the-shelf for the treatment of a large number of patients. Fate Therapeutics is a public company headquartered in San Diego, CA, with a subsidiary in Ottawa, Canada.

Press releases

Fate Therapeutics Enters Into Sponsored Research Agreement With Boston Children's Hospital to Develop Immunoregulatory Cell Therapy for Treatment of Autoimmune Diseases
Jun 05, 2015
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Fate Therapeutics Announces Pricing of Public Offering of Common Stock
May 20, 2015
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Fate Therapeutics Announces Proposed Public Offering of Common Stock
May 18, 2015
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Juno Therapeutics and Fate Therapeutics Announce Strategic Research Collaboration to Improve the Therapeutic Profile of Engineered T Cell Immunotherapies
May 06, 2015
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Fate Therapeutics Expands and Strengthens Leadership Team
Mar 03, 2015
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Fate Therapeutics Announces Key 2015 Objectives for the Advancement of Programmed Cellular Therapeutics Pipeline
Jan 12, 2015
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Fate Therapeutics Announces Interim Data From Ongoing Phase 2 PUMA Study
Dec 18, 2014
Read More
Fate Therapeutics Secures Up to $20 Million in Debt Financing
Jul 31, 2014
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Fate Therapeutics Announces FDA Clearance of IND for Clinical Development of PROHEMA in Inherited Metabolic Disorders
Jul 29, 2014
Read More
Fate Therapeutics Submits IND Application for the Clinical Development of PROHEMA(R) in Inherited Metabolic Disorders
Jun 30, 2014
Read More
Fate Therapeutics to Highlight Potential Clinical Applications of Ex Vivo Hematopoietic Cell Modulation at 12th International Cord Blood Symposium
Jun 05, 2014
Read More
Fate Therapeutics Announces FDA Clearance of IND Amendment for Clinical Development of PROHEMA(R) in Pediatric Patients
Apr 23, 2014
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Fate Therapeutics Secures U.S. Patent for Class of Small Molecule Modulators Key to the Development of iPSC-Based Therapeutics
Apr 10, 2014
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Fate Therapeutics Commences Phase 2 Clinical Trial of PROHEMA(R) for the Treatment of Hematologic Malignancies
Mar 12, 2014
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Fate Therapeutics Announces Publication of Its Proprietary Stem Cell Modulation Platform for Developing iPSC-Based Regenerative Therapeutics
Mar 06, 2014
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Fate Therapeutics Announces Observed Effects of Pharmacologic Modulation on T Cell Compartment From Its Phase 1b Study of PROHEMA(R)
Feb 26, 2014
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Fate Therapeutics Announces Closing of Initial Public Offering and Exercise of Option to Purchase Additional Shares
Oct 04, 2013
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Fate Therapeutics Presents Efficacy Data for WNT7a-Analog Program at Muscular Dystrophy Association 2013 Scientific Conference
Apr 22, 2013
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Fulcrum Therapeutics
Public
www.fulcrumtx.com
Developing new medicines by transforming gene regulation in disease.

Fulcrum Therapeutics is a biotechnology company developing new medicines to deliver a new future to patients and their families by transforming gene regulation in disease. Fulcrum's therapies are based on modulating gene regulation via control of genetic on and off switches of disease genes. Fulcrum, headquartered in Cambridge, Mass., was launched by Third Rock Ventures in 2016 and named a "Fierce 15" company later that year.

Press releases

Fulcrum Therapeutics Enters into a Collaboration and License Agreement with Sanofi for the Development and Commercialization of Losmapimod in Facioscapulohumeral Muscular Dystrophy
May 14, 2024
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Fulcrum Therapeutics Completes $68.5 Million Private Placement
Jun 10, 2020
Read More
Fulcrum Therapeutics Announces $80 million Series B Financing
Sep 05, 2018
Read More
GlycoMimetics
Public
www.glycomimetics.com
Focusing on the discovery and development of novel glycomimetic drugs to address unmet medical needs.

GlycoMimetics is a public, clinical stage biotechnology company focused on the discovery and development of novel glycomimetic drugs to address unmet medical needs resulting from diseases in which carbohydrate biology plays a key role. Using its expertise in carbohydrate chemistry and knowledge of carbohydrate biology, the company is developing a pipeline of glycomimetic drug candidates that inhibit disease-related functions of carbohydrates, such as the roles they play in inflammation, cancer and infection.

"GlycoMimetics has enjoyed a very positive and productive relationship with SV. We have appreciated the opportunity to consult with functional area experts as well as to be in regular communication about the progress of our unpartnered programs. It’s great to have a chance to be ‘on the radar screen'."

Rachel K. King
CEO, GlycoMimetics

Press releases

GlycoMimetics Completes Enrollment of Newly Diagnosed AML Patient Cohort in Phase 2 Clinical Trial of GMI-1271
Mar 07, 2017
Read More
GlycoMimetics to Receive $20 Million Payment from Pfizer Following Initiation of Phase 3 Trial with Rivipansel
Jun 23, 2015
Read More
GlycoMimetics Announces Pricing of Initial Public Offering
Jan 09, 2014
Read More
GlycoMimetics Announces EMA’s Granting of Orphan Drug Status in European Union for GMI-1070 in Sickle Cell Disease
Sep 13, 2013
Read More
GlycoMimetics Announces Top Line Results from Phase 2 Trial with GMI-1070 in Sickle Cell Disease
Apr 16, 2013
Read More
Glycomine
Private
San Carlos, California
www.glycomine.com
Developing orphan drugs for serious rare disorders of metabolism and protein misfolding.

Glycomine is developing orphan drugs for serious rare disorders of metabolism and protein misfolding for which no other therapeutic options exist. The company's approach is to use replacement therapies – substrates, enzymes, or proteins – and to target those molecules to clinically relevant cellular compartments. The company is based in San Carlos, California.

Press releases

Glycomine Announces $115 Million Series C Financing to Advance Lead Drug Candidate, GLM101, into a Phase 2b Clinical Trial for PMM2-CDG
Apr 16, 2025
Read More
Glycomine Announces First Dosing in Phase 1 Clinical Study of GLM101, a Potential Treatment for PMM2-CDG
Dec 17, 2021
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Glycomine’s Natural History Study Informs Potentially Lifesaving Update to Standard of Care for PMM2-CDG Patient
Jun 29, 2021
Read More
Glycomine Closes $68 Million Series B to Advance into Clinical Trials a Novel Treatment for PMM2-CDG, a Rare Glycosylation Disease
Jun 23, 2021
Read More
Granite Bio
Private
Basel, Switzerland
www.granitebio.com
Targeting fundamentals of inflammation, autoimmunity and fibrosis

Chronic inflammatory diseases represent the most significant cause of death globally. Patients with autoimmune, inflammatory and fibrotic conditions are lacking efficacious treatment options. Granite Bio’s first-in-class assets are designed to target fundamental disease biology.

Press releases

Granite Bio Debuts With $100 Million of Capital
Apr 23, 2025
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i2O Therapeutics
Private
Allston, MA
i2obio.com
Developing safe and effective oral formulations of therapies traditionally limited to injections.

i2O Therapeutics is a biotechnology company developing safe and effective oral formulations of therapies traditionally limited to injections. Using an innovative ionic liquid technology, this platform leverages the benefits of protecting the drug cargo while also transiently enhancing permeation across the epithelial lining when administered orally. i2O is focused on creating the next generation of oral peptide and protein-based therapies.

Press releases

i2o Therapeutics Names Kurt Graves Chairman and CEO, Announces Corporate Updates
Aug 28, 2023
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i2O Therapeutics Announces the Appointment of Kurt C. Graves as Executive Chairman
Oct 12, 2021
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i2O Therapeutics Announces Research Collaboration with Sanofi to Enable Oral Delivery of Nanobody-Based Medicines
Feb 10, 2021
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i2O Therapeutics Raises $4 million in Seed Funding Co-led by Sanofi Ventures and JDRF T1D Fund
Apr 09, 2020
Read More
Icosavax
Acquired
Seattle
www.icosavax.com
Focusing on developing safe and effective vaccines against infectious diseases.

Icosavax is focused on developing safe and effective vaccines against infectious diseases that address important unmet medical needs and reduce healthcare costs. The company was founded on breakthrough computationally-designed virus like particle technology, exclusively licensed for a variety of infectious disease indications from the Institute for Protein Design at the University of Washington. Icosavax is located in Seattle.

Press releases

Icosavax, Inc. Announces Agreement to be Acquired by AstraZeneca
Dec 11, 2023
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Icosavax Closes $100 Million Series B Financing to Advance Bivalent RSV/hMPV Vaccine Candidate Into Clinical Trials.
Apr 07, 2021
Read More
Icosavax Launches COVID-19 Vaccine Program with Preclinical Data and $16.5 Million in New Funding
Oct 30, 2020
Read More
Icosavax Launches with $51 Million Series A Financing to Advance Computationally Designed VLP Vaccines
Oct 03, 2019
Read More
Imbria Pharmaceuticals
Private
Boston, MA
imbria.com
Translating our understanding of cellular metabolism into innovative medicines.

Imbria Pharmaceuticals’ mission is to translate our understanding of cellular metabolism into innovative medicines that improve the lives of patients with limited or inadequate treatment options. The company was founded by doctors and launched by an all doctor executive team motivated by the promise of bringing new therapies to people in need. Imbria is propelled by a deep scientific interest in cellular metabolism and the mitochondria, and is guided by both values and a code of business conduct built upon their commitment to always put the patients, families and communities Imbria serves at the forefront of all that they do.

Immune Design
Public
www.immunedesign.com
Activating the immune system's natural ability to create tumor-specific cytotoxic T cells to fight cancer and other chronic diseases.

The company's technologies are engineered to activate the immune system's natural ability to create tumor-specific cytotoxic T cells to fight cancer and other chronic diseases. Immune Design's clinical programs are the product of its two synergistic discovery platforms: ZVex™ and GLAAS™. Immune Design has offices in Seattle, Washington and South San Francisco, California.

"We are very pleased that SV has decided to invest in Immune Design. Our companies share the vision of harnessing the immune system to discover and develop new immune-based therapies in a number of large human diseases in which both companies are interested."

Carlos Paya
President & CEO, Immune Design

Press releases

Immune Design Presents Data on the Mechanism of Action of G100 via TLR4 Expressed in B Cell Malignancies at the Inaugural AACR International Meeting Advances in Malignant Lymphoma
Jun 25, 2018
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Immune Design Announces Launch of Web Portal for SYNOVATE Phase 3 Study of CMB305 Immunotherapy in Synovial Sarcoma
May 24, 2018
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Immune Design Announces G100’s Receipt of Orphan Drug Designation by the EMA for the Treatment of Follicular Non-Hodgkin’s Lymphoma
Oct 19, 2017
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Immune Design Announces Positive FDA Feedback on Phase 3 Clinical Trial Design for CMB305 in Synovial Sarcoma Patients
Oct 16, 2017
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New Randomized Data From CMB305 + Checkpoint Inhibitor Study Demonstrate Greater Clinical Benefit and Immune Response
Sep 08, 2017
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Immune Design Announces New CMB305 + Checkpoint Inhibitor Topline Data from an Upcoming Presentation at the ESMO 2017 Congress
Aug 30, 2017
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New Clinical and Biomarker Data Validate Immune Design's Lead Programs and Discovery Platforms
May 17, 2017
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Immune Design to Present New Tumor Eradication Data for Systemic Plus Intratumoral Immunization at the American Association for Cancer Research (AACR) Annual Meeting 2017
Mar 01, 2017
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Immune Design Receives Orphan Drug Designation for G100 Intratumoral Product Candidate
Feb 22, 2017
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Immune Design Announces Advancement of First GLAAS™-based Allergy Program into Clinical Development
Sep 28, 2016
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Immune Design Releases New PFS, OS and TME Data from Trials of Three Immuno- Oncology Product Candidates
Jun 08, 2016
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Immune Design and Gritstone Oncology Announce Clinical Collaboration for Neoantigen Cancer Immunotherapy
May 09, 2016
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Immune Design's GLAAS™ Platform Shown to Modulate the Allergic Immune Response
Mar 04, 2016
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Immune Design Announces Positive Topline Data From Three Phase 1 Clinical Trials of Immuno-oncology Product Candidates
Feb 09, 2016
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Immune Design Receives Orphan Drug Designation From the U.S. FDA for Complementary Components of CMB305
Jan 08, 2016
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Immune Design Announces Start of Randomized Phase 2 Cancer Immunotherapy Combination Trial in Patients With Soft Tissue Sarcoma
Nov 11, 2015
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Immune Design Presents Preclinical Data on G100 and ZVex(TM) in Combination With Check Point Inhibitors at the 2015 Society for Immunotherapy of Cancer Annual Meeting
Nov 03, 2015
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MEDI7510 for Respiratory Syncytial Virus Advances to Phase 2 Leverages Immune Design's GLAAS(TM) Discovery Platform
Oct 29, 2015
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Immune Design and Merck to Collaborate on Combination Trials of Two Immune Design Immunotherapies With Merck's KEYTRUDA for Non-Hodgkin's Lymphoma and Melanoma
Aug 10, 2015
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Immune Design Prices Public Offering of Common Stock
Apr 15, 2015
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Immune Design Announces Positive Topline Data From Three Phase 1 Clinical Trials of Immuno-Oncology Agents
Mar 31, 2015
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Immune Design Announces Treatment of Patients With CMB305 Investigational Immuno- Oncology Agent
Mar 26, 2015
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Immune Design Announces First Patients Dosed in Phase 1 Clinical Trial of G100 Investigational Immuno-Oncology Agent
Feb 11, 2015
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Sanofi Pasteur and Immune Design Enter Broad Collaboration for the Development of a Herpes Simplex Virus Therapy
Oct 16, 2014
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Immune Design Added to Russell 2000(R) Index
Oct 02, 2014
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Sanofi Licenses Immune Design's GLAAS Platform to Explore Novel Approach to Treat Food Allergy
Aug 07, 2014
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Immune Design Announces Pricing of Initial Public Offering
Jul 24, 2014
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Immune Design Announces Treatment of First Patient in Phase 1 Clinical Trial of LV305 Immuno-Oncology Agent
Jun 05, 2014
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Immune Design’s GLAASTM Discovery Platform Used in MEDI7510 Phase 1 Trial for Respiratory Syncytial Virus
May 27, 2014
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Immune Design Appoints Franklin M. Berger to Board of Directors
Mar 18, 2014
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Immune Design Appoints William Ringo to Board of Directors
Mar 06, 2014
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Immune Design Announces Treatment of First Patient in Phase 1 Clinical Trial of ID-G305 Cancer Immunotherapy Agent
Feb 27, 2014
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Immune Design Announces Treatment of First Patient in Phase 1 Clinical Trial of ID-G100, an Investigational Immuno-Oncology Agent
Jan 27, 2014
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Immune Design Raises Up to $49 Million Series C Financing Proceeds to Advance Multiple Next-Generation Cancer Immunotherapy Product Candidates
Oct 30, 2013
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Inozyme Pharma
Acquired
www.inozyme.com
Developing new medicines to treat rare disorders of calcification.

Inozyme Pharma is a biotechnology company developing new medicines to treat rare disorders of calcification. These diseases are characterized by mineral imbalances, which lead to over calcification of soft tissues and under mineralization of bone. Founded in 2016 with technology licensed from Yale University, the company possesses a deep understanding of the biology of calcification which it is using to develop new medicines that have the potential to drastically improve the standard-of-care and change treatment paradigms. Inozyme’s lead candidate is an enzyme replacement therapy designed to treat calcification disorders of the circulatory system, bone and kidney for which insufficient treatment options currently exist.

Press releases

BioMarin Strengthens Enzyme Therapy Busines with Acquisition of Inozyme Pharma
May 16, 2025
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Inozyme Pharma Receives Orphan Drug Designation for INZ-701 in the United States and European Union
Jul 17, 2018
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Inozyme Pharma Offers No-Cost Genetic Testing for Rare Calcification Disorders
Jun 13, 2018
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Inozyme Pharma Raises $49 Million in a Series A Financing to Develop Therapies for Rare Diseases Affecting Soft Tissues and Bone
Nov 15, 2017
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KaloBios
Public
www.kalobios.com
Focusing on the development of monoclonal antibody therapeutics.

Prior to its relaunch as Humanigen, Inc., KaloBios was a public biopharmaceutical company focused on the development of monoclonal antibody therapeutics to treat serious medical conditions with a primary clinical focus on severe respiratory diseases and cancer.

Press releases

Publication by KaloBios and Collaborators Shows EphA3 as Target for Highly Selective Anticancer Therapy
Aug 14, 2014
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U.S. FDA Grants Orphan Drug Designation for KaloBios' KB001-A in Treatment of Cystic Fibrosis Patients
Oct 30, 2013
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KaloBios Pharmaceuticals, Inc. Prices Public Offering of Common Stock
Sep 26, 2013
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U.S. FDA Grants Fast-Track Designation to Sanofi Pasteur and KaloBios' Novel Biologic Candidate for Pseudomonas aeruginosa
Apr 23, 2013
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Kymera Therapeutics
Public
www.kymeratx.com
Pioneering a transformative new approach to treating previously untreatable diseases.

Kymera Therapeutics is a biotechnology company pioneering a transformative new approach to treating previously untreatable diseases. The company is advancing the field of targeted protein degradation, accessing the body’s innate protein recycling machinery to degrade dysregulated, disease-causing proteins. Powered by Pegasus™, a game-changing integrated degradation platform, Kymera is accelerating drug discovery with an unmatched ability to target and degrade the most intractable of proteins, and advance new treatment options for patients.

Press releases

Kymera Therapeutics Announces Pricing of Upsized Initial Public Offering
Aug 20, 2020
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Kymera Therapeutics and Sanofi Enter into Strategic Partnership to Advance Novel Protein Degrader Therapies to Patients
Jul 09, 2020
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Vertex and Kymera Therapeutics Establish Strategic Collaboration to Discover and Develop Targeted Protein Degradation Medicines for Serious Diseases
May 15, 2019
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Kymera Therapeutics Announces $65 Million Series B Financing to Advance Pipeline of Targeted Protein Degraders in Oncology and Immunology
Nov 13, 2018
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Latigo
Private
Thousand Oaks, CA
www.latigobio.com
Best in class therapies for acute and chronic pain

Latigo is clinical stage company advancing a pipeline of Nav1.8 inhibiting small molecules for both acute and chronic pain.

Press releases

Latigo Biotherapeutics Closes $150 Million in Series B Financing to Advance Non- Opioid Pain Therapeutics
Mar 17, 2025
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LAVA Therapeutics
Public
Utrecht, Netherlands / Philadelphia, USA
lavatherapeutics.com
Developing a proprietary bispecific antibody platform that engages gamma-delta T cells.

LAVA Therapeutics is developing a proprietary bispecific antibody platform that engages gamma-delta T cells for the treatment of hematological and solid cancers. The company’s first-in-class immuno-oncology approach activates Vγ9Vδ2 T cells upon binding to membrane-expressed tumor targets. LAVA was founded in 2016 based on intellectual property originating from the Amsterdam University Medical Center. The company has established a highly experienced antibody research and development team located in Utrecht, the Netherlands (headquarters) and Philadelphia, USA.

Press releases

LAVA Therapeutics Announces Pricing of Initial Public Offering.
Mar 24, 2021
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LAVA Therapeutics Appoints Edward F. Smith as Chief Financial Officer.
Mar 15, 2021
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Lava Therapeutics appoints Dr. Kapil Dhingra as Chairman of the Board of Directors in Advance of Lead Program Entering the Clinic.
Feb 22, 2021
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LAVA Therapeutics Announces $83 million Series C Financing to Advance Novel Immuno-Oncology Programs
Sep 17, 2020
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Lumena Pharmaceuticals
Acquired
Dedicated to providing better treatment options for rare and debilitating liver diseases and serious metabolic disorders.

Lumena Pharmaceuticals, acquired by Shire plc in June 2014, is a biopharmaceutical company dedicated to providing better treatment options for adults and children who suffer from rare and debilitating liver diseases and serious metabolic disorders. The company is focused on developing oral therapeutics to improve liver function, relieve disease symptoms and dramatically benefit patient health.

Press releases

Shire Adds to Rare Disease Portfolio with Acquisition of Lumena Pharmaceuticals, Bringing Late Stage Compounds for Rare GI/Hepatic Conditions
May 12, 2014
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Lysosomal Therapeutics
Acquired
www.lysosomaltx.com
Dedicated to innovative small molecule research and development in the field of neurodegeneration.

Lysosomal Therapeutics Inc. (LTI) is dedicated to innovative small molecule research and development in the field of neurodegeneration, yielding new treatment options for patients with severe neurological diseases. Our strategy leverages the clinically-validated link between lysosome-based genetic disorders and neurodegenerative diseases to establish a unique and effective molecular platform for novel drug discovery. LTI’s lead program targets Gaucher-related neurodegeneration, Parkinson’s disease and other synucleinopathies.

Press releases

BIAL Goes Global with New US Research Center and Acquisition of Promising Parkinson's Disease Programs
Oct 01, 2020
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Lysosomal Therapeutics Inc. Raises $20 Million in Series A Financing
Feb 03, 2015
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Lysosomal Therapeutics Inc. Receives $4.8 Million in Seed Funding
May 12, 2014
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MacroGenics
Public
www.macrogenics.com
Focusing on discovering and developing innovative monoclonal antibody-based therapeutics.

MacroGenics is a clinical-stage biopharmaceutical company focused on discovering and developing innovative monoclonal antibody-based therapeutics for the treatment of cancer and autoimmune diseases. The company generates its pipeline of product candidates from its proprietary suite of next-generation antibody technology platforms, which it believes improve the performance of monoclonal antibodies and antibody-derived molecules. The company creates both differentiated molecules that are directed to novel cancer targets, as well as "bio-betters," which are drugs designed to improve upon marketed medicines. The combination of MacroGenics' technology platforms and antibody engineering expertise has allowed the company to generate promising product candidates and enter into several strategic collaborations with global pharmaceutical and biotechnology companies.

Matchpoint Therapeutics
Private
Cambridge, MA
www.matchpointtx.com
A biotechnology company founded to leverage the power of covalency for the discovery of precision small molecule medicines.

Matchpoint is a biotechnology company harnessing the power of covalency to discover precision covalent medicines to transform the treatment of immune diseases and other serious illnesses. The company's proprietary Advanced Covalent Exploration (ACE) platform integrates advanced chemoproteomics, machine learning and covalent chemistry library evolution. Matchpoint has an emerging pipeline of novel covalent medicines initially focused on immunology.

Press releases

Matchpoint Therapeutics Launches with $100 Million to Deliver on the Promise of Precision Covalent Medicines for Immune Diseases
Oct 14, 2022
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Medisafe
Private
Haifa, Israel and Boston, MA, USA
www.medisafe.com
Delivering a next-generation patient engagement and medication adherence solution.

Medisafe is the largest medication management platform with over 7M registered users globally. Medisafe’s growth is rapidly accelerating as the healthcare industry turns to digital health solutions to support patients. • The Medisafe digital health platform delivers a next-generation patient engagement and medication adherence solution which leverages an AI data-driven personalization engine to improve health outcomes across a broad range of therapeutic areas with ecosystem integration and clinical validation.

Press releases

New Analysis Shows Reduction in Annual Patient Costs and Medical Claims with Medisafe
Sep 06, 2023
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Medisafe Expands Business Solutions with New Software as a Medical Device (SaMD)
Jan 04, 2023
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Medisafe Secures $30M in Series C Funding led by Sanofi Ventures and ALIVE Israel HealthTech Fund to Build Future Model of Patient Support.
Feb 25, 2021
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Minervax
Private
Copenhagen, Denmark
minervax.com
Developing a prophylactic vaccine against Group B Streptococcus.

Minervax is a clinical stage biotechnology company developing a prophylactic vaccine against Group B Streptococcus (GBS). Minervax’s protein only GBS vaccine targets maternal populations for the prevention of adverse pregnancy outcomes and life-threatening infections in newborns. The company was established in 2010 based on research from Lund University and is based in Copenhagen, Denmark.

Press releases

MinervaX and Wacker Biotech Announce Manufacturing Collaboration for Prophylactic Vaccine Targeting Group B Streptococcus
Sep 17, 2024
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MinervaX Raises EUR 54M in Upsized Financing to Advance the Development of its Maternal Vaccine Against Group B Streptococcus
Oct 11, 2023
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MinervaX Announces Completion of Enrolment in Phase I Clinical Vaccine Trial as it Addresses the Global Burden of Group B Streptococcus in Older Adults
Jun 27, 2023
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MinervaX Commences First Phase 1 Clinical Study of Novel GBS Vaccine in Older Adults
Apr 17, 2023
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MinervaX appoints Lidia Oostvogels as Chief Medical Officer and provides clinical and regulatory update on its novel GBS vaccine
Jan 05, 2023
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MinervaX announces 72M EUR financing to advance development of novel vaccine against Group B Streptococcus
Dec 16, 2022
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MinervaX Provides Clinical Update on its Maternal GBS Vaccine
Feb 14, 2022
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MinervaX provides clinical and leadership update
Oct 07, 2021
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MinervaX raises upsized EUR 47.4M (USD 57M) Series B to advance its novel Group B Streptococcus vaccine through mid-stage clinical trials
Dec 15, 2020
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Mirador Therapeutics
Private
San Diego
www.miradortx.com
Mirador is a next-generation precision medicine company focused on immunology and inflammation.

Mirador is leveraging the latest advances in human genetics and cutting-edge data science to rapidly advance new precision medicines for patients living with chronic immune-mediated inflammatory and fibrotic diseases.

Press releases

Mirador Therapeutics Launches to Accelerate the Next Generation of Precision Medicines for Immune- mediated Diseases
Mar 22, 2024
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Muna Therapeutics
Private
Copenhagen, Denmark
www.munatherapeutics.com
Discovering therapies that slow or stop devastating neurodegenerative diseases.

Muna Therapeutics discovers and develops therapies that slow or stop devastating neurodegenerative diseases including Alzheimer’s, Frontotemporal Dementia and Parkinson’s. These disorders impact memory, movement, language, behavior and personality resulting in disability and death of millions of patients around the globe. Muna focuses on identifying new medicines to preserve cognition and other brain functions and enhance resilience to neurodegenerative diseases.

Press releases

Muna Therapeutics Announces Strategic Alliance with GSK to Accelerate Development of Novel Treatments for Alzheimer’s Disease
Dec 05, 2024
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Muna Therapeutics Awarded $4.9M Grant from The Michael J. Fox Foundation for Parkinson’s Research Supports Development of Disease Modifying Therapy for Parkinson’s Disease
Oct 11, 2022
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Muna Therapeutics Appoints Dr. Niels Plath as Chief Scientific Officer
Nov 02, 2021
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Muna Therapeutics appoints Dr. Donald Nicholson as Independent Chair of Board of Directors
Sep 13, 2021
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Muna Therapeutics Launches with US$ 73M Series A to Advance Novel Small Molecule Therapeutics for Neurodegenerative Diseases
Jun 30, 2021
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Navitor
Private
Cambridge, MA
www.navitorpharma.com
Designing therapeutics to selectively modulate the cellular signals that are aberrant in disease processes.

Navitor is pioneering the selective targeting of mTORC1 activation to develop a new class of medicines for age-related diseases to improve human health. Navitor’s therapeutics are designed to selectively modulate the cellular signals that are aberrant in disease processes caused by the dysregulation of mTORC1 activation to address a wide range of diseases, including metabolic, neurodegenerative, autoimmune and musculoskeletal diseases, as well as age‐related immune suppression and several rare disorders. The company’s founding intellectual property is based on the groundbreaking discoveries related to the mTORC1 pathway and nutrient signaling mechanisms by Dr. David Sabatini at The Whitehead Institute for Biomedical Research.

Press releases

Navitor Pharmaceuticals Announces Janssen Has Acquired Anakuria Therapeutics, Inc.
Feb 02, 2022
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Navitor Pharmaceuticals Commences Phase 1 Clinical Evaluation of NV-5138, a Novel mTORC1 Activator in Patients with Treatment-Resistant Depression
Jan 24, 2019
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Navitor Pharmaceuticals Appoints Thomas E. Hughes, Ph.D. as Chief Executive Officer
Aug 02, 2018
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Navitor Pharmaceuticals Initiates a Clinical Study of NV‐5138, a Novel, Oral Small Molecule for Treatment‐ Resistant Depression
Jun 26, 2018
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Navitor Pharmaceuticals Announces $33 Million Series B Financing
Dec 18, 2015
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NextPoint Therapeutics
Private
Cambridge, MA
www.nextpointtx.com
NextPoint is advancing the field of immuno-oncology through its leading scientific work on the novel HHLA2 pathway.

NextPoint is advancing the field of immuno-oncology through its leading scientific work on HHLA2 biology; integrating foundational science with a defined clinical biomarker to deliver a new class of monotherapies for patients who will not benefit from PD-1/L1 inhibitors.

Press releases

NextPoint Therapeutics Announces First-in-class T Cell Engager NPX372 As New Drug Candidate Targeting B7-H7 in Solid Tumors
Sep 05, 2024
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NextPoint Therapeutics Chief Executive Officer Ivan Cheung Named to the 2024 TIME100 Health List
May 06, 2024
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NextPoint Therapeutics Announces Closing of Series B Financing Extension led by Catalio Capital Management
Feb 14, 2024
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NextPoint Therapeutics Appoints Ivan Cheung as Chief Executive Officer
Feb 01, 2024
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Axel Hoos, MD, PhD, Joins NextPoint Therapeutics Board of Directors
Mar 21, 2023
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NextPoint Therapeutics Appoints Leena Gandhi, MD, PhD, as Chief Medical Officer
Feb 21, 2023
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NextPoint Therapeutics Announces $80 Million Series B Financing co-led by Leaps by Bayer and Sanofi Ventures to Advance Novel Immuno-Oncology Programs
Jan 10, 2023
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NodThera
Private
Cambridge, UK
NodThera.com
Developing a new class of potent and selective NLRP3 inflammasome inhibitors.

NodThera is a biotechnology company developing a new class of potent and selective NLRP3 inflammasome inhibitors for the treatment of diseases driven by chronic inflammation.

Press releases

NodThera Named a ‘Fierce 15’ Company by Fierce Biotech
Aug 05, 2024
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NodThera Announces Appointment of Greg Chow as Chief Financial and Business Officer
Aug 01, 2024
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NodThera’s NLRP3 Inhibitor NT-0796 Meets Primary Endpoint of Inflammation Reversal in Phase Ib/IIa Trial in Obese Subjects with Cardiovascular Risk
Jun 12, 2024
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NodThera Announces Appointment of Daniel Swisher as Chief Executive Officer
May 28, 2024
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NodThera’s NLRP3 Inhibitor NT-0796 Reverses Neuroinflammation in Parkinson’s Disease Phase Ib/IIa Trial
Mar 07, 2024
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NodThera Publishes Preclinical Data Demonstrating Reversal of Obesity and Inflammation with Clinical-stage Brain-penetrant NLRP3 Inflammasome Inhibitors
Feb 20, 2024
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NodThera Announces Appointment of Dr. Thomas Jaecklin as Chief Medical Officer
Feb 05, 2024
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NodThera announces first patients dosed in a Phase Ib/IIa cardiovascular risk trial of NLRP3 inflammasome inhibitor NT-0796
Oct 16, 2023
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NodThera is first to demonstrate reduction in neuroinflammation in the clinic with brain penetrant NLRP3 inflammasome inhibitor
Jul 11, 2023
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NodThera announces positive first-in-human data for two brain penetrant NLRP3 inflammasome inhibitors
Jun 20, 2023
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NodThera Announces Positive Phase 1 Study Readouts for the NLRP3 Inflammasome Inhibitors NT-0796 and NT-0249
Sep 21, 2022
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NodThera Announces Clinical Progress for Lead NLRP3 Inflammasome Inhibitors and Candidate Selection of Novel Brain-Penetrant Compound
May 10, 2022
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NodThera Announces Progress of NT-0796, a Novel NLRP3 Inflammasome Inhibitor, into a Phase 1 First-in-Human Study
Nov 04, 2021
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NodThera Appoints Chief Medical Officer and Chief Financial Officer
Dec 15, 2020
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NodThera Announces Close of $55 Million Series B Financing
Oct 28, 2020
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Normunity
Private
West Haven, Connecticut
www.normunity.com
A biotechnology company identifying and targeting novel mechanisms to remove cancer's barriers to normal immunity.

Normunity's initial drug discovery is focused on the challenge of immune cell exclusion, targeting mechanisms of trafficking to and infiltration into the tumor-- critical steps to turn a cold tumor hot. Normunity's therapies are immune normalizers that will be used as precision medicines for the treatment of cancer. By eliminating cancer’s defenses, immune normalizers free immune cells to carry out their expected work of recognizing and eliminating cancer.

Press releases

Normunity closes $75 million Series B financing to advance lead drug program into the clinic and broaden pipeline of novel anti-cancer therapies targeting untapped drug mechanisms
Jan 13, 2025
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Normunity announces $65 million Series A financing to expand the frontier of precision immuno-oncology with immune normalizer therapies
Oct 25, 2022
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nucleai
Private
Tel Aviv, Israel / Chicago, USA
www.nucleai.ai
Nucleai is Leading the Spatial Biology Revolution in Precision Medicine

Nucleai is committed to bringing the power of spatial biology to reality by providing pharmaceutical companies and clinicians with AI-powered image analysis applications. Nucleai's platform enhances drug development, supports treatment decisions and improves patient lives.

Nucleai's image analysis and biomarker discovery technology leverages real-world pathology, clinical and molecular datasets to better understand cancer biology, optimize patient stratification and improve patient care.

Press releases

Merck’s Corporate Venture M Ventures Arm Backs Nucleai to Advance Its First-in-class Spatial AI Biomarker in Active Clinical Enrollment
Apr 03, 2024
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Nucleai Closes $33 Million Series B Financing to Advance Spatial Biology Platform for Drug Research, Development and Diagnostics
Mar 22, 2022
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Nura Bio
Private
San Francisco, CA
www.nurabio.com
Developing neuroprotective therapies for the treatment of a broad range of neurological diseases.

Nura Bio is a clinical-stage biopharmaceutical company developing neuroprotective therapies for the treatment of a broad range of neurological diseases. Nura Bio’s research and early development small molecule pipeline is focused on developing therapies that halt axon degeneration and/or modulate microglial responses to degeneration and injury, with the goal of conferring neuroprotection, across diseases of the central, peripheral, and ocular nervous systems.

Press releases

Nura Bio Closes Series A Financing with $68 Million in New Funds, Bringing Total Raised to $140+ Million
Sep 17, 2024
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Nuvig Therapeutics
Private
Menlo Park, CA
www.nuvigtherapeutics.com
Developing a first-in-class Fc fragment immunomodulator aimed at improving autoimmune dysregulation without suppressing the immune system.

Nuvig Therapeutics is a biotechnology company developing a recombinant, engineered Fc fragment (NVG-2089) that binds to type II Fc receptors and recapitulates the immunomodulatory effect of intravenous immunoglobulin (IVIg). NVG-2809 has the potential for a highly differentiated profile across a range of autoimmune indications. NVG-2089 has completed Phase 1 in healthy volunteers and is advancing into a proof-of-concept study in Chronic Inflammatory Demyelinating Polyneuropathy (CIDP).

Press releases

Nuvig Therapeutics Announces $161 Million Series B Financing and Progression to Phase 2 Development with Novel, Second-Generation Immunomodulator
Dec 05, 2024
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Odyssey Therapeutics
Private
Cambridge, MA
www.odysseytx.com
Odyssey is advancing a pipeline of potential first and best in class immunology and oncology programs.

Odyssey Therapeutics is focused on discovering, developing, and commercializing the next generation of immunomodulators and oncology medicines. Composed of an expert team of drug hunters, scientists and industry leaders in foundational biology, chemistry and data sciences, Odyssey is transforming drug discovery to accelerate and drive the creation and efficient delivery of life-enhancing precision medicines to patients.

Omada Health
Private
San Francisco, CA
www.omadahealth.com
Enabling people to change the habits that put them most at risk for chronic conditions.

Omada Health is a digital behavioral medicine company that inspires and enables people to change the habits that put them most at risk for chronic conditions like heart disease and type 2 diabetes. The company is the largest CDC-recognized provider of the National Diabetes Prevention Program, and since its founding, has enrolled more than 100,000 participants. Omada’s program combines proven behavioral science, the power of professional health coaches and peer groups, connected technology, and world-class design to deliver clinically-meaningful results.

Press releases

Omada Health Becomes the First Fully-Digital Company to Earn URAC Accreditation for Musculoskeletal (MSK) Care
Aug 01, 2023
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Omada Health Closes $192 Million Series E Financing to Bring Virtual-First Care to Millions
Feb 23, 2022
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Omada Health Raises $73 Million to Accelerate Program Expansion
Jun 26, 2019
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Omada Health Adds New Programs for Type 2 Diabetes and Hypertension Self-Management
Jun 20, 2018
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OMass
Private
Oxford, UK
www.omass.com
Identifying new medicines using novel biochemistry techniques, native mass spectrometry and custom chemistry

OMass Therapeutics is a biotechnology company discovering medicines against highly-validated target ecosystems, such as membrane proteins or intracellular complexes. The company’s unique OdyssION™ technology platform comprises novel biochemistry techniques, next-generation native mass spectrometry, and custom chemistry. This allows OMass to interrogate not just the target, but also the interaction of the target with its native ecosystem, separate from the confounding complexity of the cell. The result is cell-system fidelity with cell-free precision. OMass is advancing a pipeline of small molecule therapeutics in rare diseases and immunological conditions, therapeutics that target solute carriers, complex-bound proteins, and GPCRs.

Press releases

OMass Therapeutics appoints Birgitte Volck as Non-Executive Director
Feb 26, 2025
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OMass Therapeutics Expands Development Team with Key Appointments in US and UK and Announces the Nomination of Clinical Candidate Against MC2
Sep 30, 2024
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OMass Therapeutics Announces Appointment of New Board Chair and Series B Extension
May 15, 2023
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OMass Therapeutics Announces New Phase of Growth with Move to New Facilities and Team Expansion to Support Portfolio Progress
Apr 19, 2023
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Publication in Nature Chemistry Demonstrates the Benefits of Native Mass Spectrometry in the Interrogation of Target Ecosystems and Drug Discovery
Nov 10, 2022
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OMass Therapeutics Raises $100 Million in Series B Financing to Progress Drug Pipeline in Immunology and Rare Diseases
Apr 28, 2022
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Ovid Therapeutics
Public
www.ovidrx.com
Committed to transforming the lives of patients with rare and orphan diseases of the brain.

Ovid Therapeutics Inc. is a public, New York based, biopharmaceutical company committed to transforming the lives of patients with rare and orphan diseases of the brain. Ovid focuses on patients and their unmet medical needs. Using the significant operational, product development and business development experience of its management team, Ovid aims to become a leading neurology company, with multiple products and a rich pipeline, coupled with compelling research and development.

Press releases

Ovid Therapeutics Announces Election of Bart Friedman to Its Board of Directors
Oct 29, 2021
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Ovid Therapeutics Receives “Company Making a Difference Award” from CDKL5 Deficiency Disorder Community
Oct 22, 2018
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Ovid Therapeutics Announces Phase 2 STARS Topline Data Accepted for Presentation at American Academy of Child And Adolescent Psychiatry Annual Meeting
Aug 16, 2018
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Ovid Therapeutics Announces OV101 Granted Fast Track Designation by U.S. FDA for Treatment of Angelman Syndrome
Dec 19, 2017
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Ovid Therapeutics Announces TAK-935/OV935 Has Received Orphan Drug Designation from U.S. FDA for Treatment of Dravet Syndrome
Dec 05, 2017
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Ovid Therapeutics Announces Positive Preclinical OV101 Data Demonstrating Behavioral Improvements in Fragile X Syndrome Model
Oct 16, 2017
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Ovid Therapeutics Appoints Ana C. Ward as Senior Vice President and General Counsel
Sep 06, 2017
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Ovid Therapeutics to be Added to Russell 2000®, 3000® and Microcap® Indexes
Jun 23, 2017
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Ovid Therapeutics Announces Initiation of Phase 1 Clinical Trial of OV101 for Adolescents with Angelman Syndrome or Fragile X Syndrome
Apr 10, 2017
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Ovid Therapeutics Announces First Patient Randomized in the Phase 2 STARS Clinical Trial in Adults with Angelman Syndrome
Feb 09, 2017
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Ovid Therapeutics and NeuroPointDX Announce Collaboration to Identify Biomarkers for Angelman Syndrome
Feb 09, 2017
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Ovid Therapeutics Names Jacqueline A. French, M.D., to Scientific Advisory Board
Jan 19, 2017
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Ovid Therapeutics Receives Orphan Drug Designation from the U.S. FDA for OV101 for the Treatment of Patients with Angelman Syndrome
Sep 08, 2016
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Ovid Therapeutics Appoints Dr. Jerome B. Zeldis to Its Scientific Advisory Board
Oct 08, 2015
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Ovid Therapeutics Appoints Dr. Karen Bernstein to its Board of Directors
Sep 30, 2015
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Ovid is developing therapies for rare and orphan diseases of the brain based on novel and proprietary insights into the genetics and molecular biology of neurological disorders
Aug 11, 2015
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Proteostasis Therapeutics
Public
www.proteostasis.com
Developing disease-modifying therapeutics for diseases of protein processing.

Proteostasis Therapeutics, Inc. (PTI) is developing disease-modifying therapeutics for diseases of protein processing. Using the DRT™ platform, a phenotypic screening approach based on the use of functionally pertinent cellular assays and disease relevant models, PTI identifies highly selective drug candidates that modulate the proteostasis imbalance in the cell. PTI's lead program is focused on treating cystic fibrosis. 

Press releases

PROTEOSTASIS THERAPEUTICS, INC. ANNOUNCES PRICING OF INITIAL PUBLIC OFFERING
Feb 11, 2016
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PROTEOSTASIS THERAPEUTICS, INC. ANNOUNCES MANAGEMENT CHANGES TO STRENGTHEN RESEARCH AND DEVELOPMENT ORGANIZATION
Dec 11, 2015
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Proteostasis Therapeutics, Inc. Demonstrates Therapeutic Potential of a Proprietary Triple Combination Therapy for the Treatment of Cystic Fibrosis that Restores Activity of Mutant F508del CFTR protein to 80% of Normal
Nov 20, 2015
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Proteostasis Therapeutics, Inc. Presents Preclinical Data for Its CFTR Amplifier Program at the 29th Annual North American Cystic Fibrosis Conference
Oct 08, 2015
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Proteostasis Therapeutics, Inc. Raises $37 Million in Crossover Financing
Sep 08, 2015
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Proteostasis Therapeutics Announces a New Class of Agents for Cystic Fibrosis Called CFTR Amplifiers and Selects PTI130 as a Development Candidate
Feb 04, 2015
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Proteostasis Therapeutics Announces Appointment of Dr. Po-Shun Lee as Vice President of Clinical Development
Dec 03, 2014
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Proteostasis Therapeutics Announces Scientific Publication in Cell Reports
Nov 06, 2014
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Proteostasis Therapeutics and Astellas Announce Collaboration for Research, Development and Commercialization of Therapies Modulating the Unfolded Protein Response
Nov 04, 2014
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Proteostasis Therapeutics Announces Appointments of Cystic Fibrosis Experts to Inaugural Clinical Advisory Board
Oct 20, 2014
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Proteostasis Therapeutics Announces Achievement of Preclinical Milestone in Neurodegenerative Diseases Collaboration with Biogen Idec
Jul 30, 2014
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Proteostasis Therapeutics Presents Promising Preclinical Data at the 27th Annual North American Cystic Fibrosis Conference
Oct 18, 2013
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Q32 Bio
Private
Cambridge, MA
q32bio.com
Developing biologics to restore healthy immune regulation.

Q32 Bio, a biotechnology company developing biologics to restore healthy immune regulation.

Press releases

Q32 Bio Launches to Develop Novel Therapeutics Targeting Regulators of Innate and Adaptive Immunity
May 27, 2020
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Q32 Bio Closes $60 Million Series B Financing, Advances to Clinical Stage Research in Therapeutics Designed to Restore Immune Homeostasis
Feb 09, 2020
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QurAlis
Private
Cambridge, MA
QurAlis.com
QurAlis is a clinical-stage biotechnology company developing breakthrough precision medicines for amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases.

QurAlis is a clinical-stage biotechnology company pioneering the path to conquering amyotrophic lateral sclerosis (ALS)and other neurodegenerative diseases through development of next-generation precision medicines to genetically validated targets. QurAlis is advancing a deep pipeline of antisense oligonucleotides (ASOs) and small molecule programs addressing sub-forms of ALS that account for the majority of ALS patients. The Company is also leveraging its proprietary platforms, unique biomarkers, and successes in ALS to expand QurAlis’ pipeline to other neurodegenerative diseases, such as frontotemporal dementia (FTD).

Press releases

QurAlis Announces Exclusive License on Novel Mechanism for Fragile X Syndrome (FXS) to Enable Development of First Potential Disease-Modifying Therapy
May 16, 2025
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Quiver Bioscience and QurAlis Announce Research Collaboration to Advance Novel Therapeutic Approach for Fragile X Syndrome
May 16, 2025
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QurAlis Announces Topline Data From its Phase 1 Clinical Trial of QRL-101 Evaluating Biomarkers of ALS and Epilepsy in Healthy Volunteers
Mar 24, 2025
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QurAlis to Participate in Upcoming Investor Conferences in March
Feb 25, 2025
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QurAlis Invited to Present at 43rd Annual J.P. Morgan Healthcare Conference
Jan 13, 2025
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QurAlis Doses First Patient With ALS in Phase 1 Clinical Trial Evaluating QRL-101, a First-in- Class Kv7 Precision Therapy for ALS
Dec 04, 2024
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QurAlis’ ANQUR Clinical Trial of QRL-201 in ALS Advances to Dose Range-Finding (DRF) Phase With First Participant Dosed
Nov 19, 2024
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QurAlis Announces Expansion of its Selective Kv7.2/7.3 Ion Channel Opener, QRL-101, Into Epilepsy
Sep 19, 2024
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QurAlis Doses First Participant Cohort in Phase 1 Multiple-Ascending Dose (MAD) Clinical Trial Evaluating QRL-101, a First-in-Class Kv7 Precision Therapy for ALS
Sep 10, 2024
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QurAlis Expands its Industry-Leading Precision Medicine Approach in Splicing Targets Beyond Neurodegeneration Into Fragile X Syndrome (FXS)
Jun 25, 2024
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QurAlis Expands Leadership Team With Doug Williamson, M.D., as Chief Medical Officer and Jason Brown, MBA, as Chief Financial Officer and Appoints Shafique Virani, M.D., to Board of Directors
Jun 11, 2024
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QurAlis Grants Lilly Exclusive Global License for QRL-204, a Potentially First-in-Class Precision Therapy That Restores UNC13A Function in ALS and FTD
Jun 03, 2024
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QurAlis to Present Data That Show its Splice-Switching ASOs Restore UNC13A Function in ALS and Frontotemporal Dementia
Mar 04, 2024
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QurAlis Strengthens Global Presence With Opening of European Headquarters That Includes R&D Manufacturing
Jan 03, 2024
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QurAlis to Present Data Showing Link Between TDP-43 Pathology and Role of UNC13A in Neuronal Biology Related to ALS and Other Neurodegenerative Diseases
Sep 06, 2023
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QurAlis and Unlearn Announce Collaboration to Accelerate and Optimize ALS Clinical Trials With Generative Artificial Intelligence Technologies
Jun 27, 2023
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QurAlis’ FlexASOs Show High Potency and Improved Safety Over Standard ASOs
Jun 08, 2023
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QurAlis Receives Clinical Trial Authorisation (CTA) in European Union (EU) for QRL-201, a First-in-Class STATHMIN-2 Precision Therapy for ALS
Jun 06, 2023
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QurAlis Announces First Patient Dosed With QRL-201, a First-in-Class STATHMIN-2 Precision Therapy for ALS
Apr 06, 2023
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QurAlis Closes $88 Million Series B Financing to Advance Precision Medicines for Neurodegenerative Diseases
Mar 09, 2023
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ReCode
Private
Menlo Park, California
www.recodetx.com
Developing disease-modifying therapeutics.

ReCode Therapeutics is an integrated genetic medicines company developing disease-modifying therapeutics using its powerful LNP delivery technology to target organs and tissues beyond the liver.

Press releases

Intellia Therapeutics and ReCode Therapeutics Announce Strategic Collaboration to Develop Novel Gene Editing Therapies for Cystic Fibrosis
Feb 15, 2024
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ReCode Therapeutics Announces Closing of Extension to Series B Financing
Sep 19, 2023
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ReCode Therapeutics Appoints Shehnaaz Suliman, M.D., MBA, M.Phil., as Chief Executive Officer
Jan 10, 2022
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ReCode Therapeutics Raises Oversubscribed Series B Financing Round of $80 Million
Oct 21, 2021
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Rome Therapeutics
Private
Cambridge, MA
www.rometx.com
Developing novel therapies for cancer and autoimmune diseases.

ROME Therapeutics is developing novel therapies for cancer and autoimmune diseases by harnessing the power of the repeatome – vast stretches of uncharted genetic material that have long been dismissed as “junk DNA.” With several drug targets identified and multiple discovery programs underway, ROME is moving rapidly to leverage this new frontier in biology. To lead this exploration, ROME has assembled a team of world-class leaders across fields including oncology, immunology, virology and machine learning. ROME is based in Cambridge, Mass.

Press releases

ROME Publishes Landmark Nature Paper Revealing First High- Resolution Structure of LINE-1 Reverse Transcriptase (RT) for Drug Discovery
Dec 14, 2023
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ROME Therapeutics Closes Oversubscribed $72 Million Series B Extension to Support Advancement of Lead Program into Clinical Development for Autoimmune Disease
Sep 12, 2023
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ROME Therapeutics Secures $77 Million in Series B Financing to Advance Repeatome-derived Pipeline for Cancer and Autoimmune Diseases and Expand Repeatomics Platform
Sep 14, 2021
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Science37
Private
Los Angeles, CA
www.science37.com
Enabling better, faster, people-powered science.

Science 37 has created a new clinical trial operating model – the metasite™ – that unlocks access so researchers can find the right patients, and patients can find the right trials. Its Network Oriented Research Assistant, NORA™, is an accelerated patient-centric mobile research platform that connects everyone safely and securely. Science 37 offers end-to-end clinical trial services without geographic limitations, making clinical research faster to accelerate biomedical discovery. Ultimately, Science 37 enables better, faster, people-powered science and brings clinical trials to scale.

Press releases

Science 37®, the Operating System for Agile Clinical Trials, Closes Business Combination with LifeSci Acquisition II Corp. and Will Begin Trading on Nasdaq as SNCE
Oct 08, 2021
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Science 37 to Become Publicly Listed via Merger with LifeSci Acquisition II Corp., Powering the Clinical Trial Operating System of the Future
May 07, 2021
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Science 37® Raises $40 Million to Extend its Leadership in the Decentralized Clinical Trial Market
Aug 20, 2020
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Science 37 Raises $29M To Bring Clinical Trials Directly Into Patients’ Homes
Apr 25, 2017
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Science 37 and Sanofi Introduce a New Partnership
Mar 01, 2017
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Science 37 Secures $31M Series B Funding to Expand Clinical Trial Access to Anyone, Anywhere, Anytime
Oct 18, 2016
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Selecta Biosciences
Public
www.selectabio.com
Developing immune modulating nanomedicines that enable novel biologic therapies by preventing harmful immune responses.

Selecta is developing immune modulating nanomedicines that enable novel biologic therapies by preventing harmful immune responses. Proprietary Synthetic Vaccine Particles (SVP) elicit lasting and antigen-specific tolerance to co-formulated biologic drugs. Selecta is conducting clinical studies to develop the first non-immunogenic biologic therapy to treat severe gout and is focused in the near-term on developing immunotherapeutic candidates that eliminate immune responses to adeno-associated virus (AAV) vectors that would enable a wide range of new applications for gene therapies.

"Sanofi has been a pioneer in recognizing the importance of antigen-specific immune modulation in vaccines, allergies, enzyme replacement therapy and auto-immune diseases. SV is of tremendous help to facilitate our dialogue within Sanofi and an esteemed member of our investor network." 

Werner Cautreels, President & CEO, Selecta Biosciences

Press releases

Selecta Announces $38 Million Series E Equity Financing
Sep 08, 2015
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Subo Biosciences
Private
Carmel, IN
www.sudobio.com
Advancing best-in-class TYK2 targeted drugs.

Sudo Biosciences is advancing a pipeline of programs targeting the tyrosine kinase 2 (TYK2) pseudokinase domain. TYK2 is a key mediator in cytokine signaling pathways that have been linked to a broad range of immune-mediated inflammatory conditions. The company’s pipeline of next generation TYK2 inhibitors includes a potential first- and best-in-class brain-penetrant candidate for the treatment of multiple sclerosis and neurodegenerative diseases with underlying neuroinflammation and a potential first- and best-in-class topical candidate for immune-mediated dermatologic diseases.

Press releases

Sudo Biosciences Announces First Participants Dosed in Phase 1 Trial of Brain-Penetrant Allosteric TYK2 Inhibitor SUDO-550
Dec 02, 2024
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Sudo Biosciences Announces Second Close of Upsized Series BFinancing Bringing Total Raised in Round to $147M
Feb 13, 2024
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Sudo Biosciences Raises $116M Series B Financing to Advance Potential Best-in- Class TYK2 Therapeutics Programs into the Clinic
Dec 20, 2023
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T-Therapeutics
Private
Cambridge, U
www.t-therapeutics.com
Developing next generation TCR therapeutics to transform cancer treatment

T-Therapeutics is a next-generation T cell receptor (TCR) company spun off from the University of Cambridge. The company was created to harness the power of T cell biology, evolved over millions of years, to create safe and effective treatments for many cancers and autoimmune diseases.

We combine world-leading expertise in mouse genome engineering, deep expertise in biopharmaceutical drug development, single cell genomics, machine-learning and structural biology, anchored in a culture of creativity and collaboration.

We are developing ‘optimal’ TCR based therapeutics using our proprietary OpTiMus® platform, based on a fully humanized TCR mouse that provides an almost unlimited source of unique, antigen-specific human TCRs. These TCRs are directed at multiple target classes, many of which have never been worked on before. We are developing a pipeline of first-in-class drugs that will become transformative medicines, reshaping the clinical landscape for patients with cancer or autoimmune diseases.

Press releases

T-Therapeutics appoints Theodora Harold as Chief Executive Officer, reflecting Company’s ambitious growth plans and progression into therapeutic development
Mar 06, 2025
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T-Therapeutics appoints Dr David Hung as Chairman
Jun 12, 2024
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T-Therapeutics raises £48 million Series A for development of next generation TCR therapeutics to transform cancer treatment
Nov 15, 2023
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Therini Bio
Private
South San Francisco, CA
therinibio.com
Focusing on developing novel therapies based on a deep understanding of fibrin.

Therini Bio, Inc. is a vascular biology company focused on developing novel therapies based on a deep understanding of fibrin and its role in driving pathological inflammatory processes initiated by loss of vascular integrity. Our initial focus is on inflammation in neurodegenerative diseases, but the mechanism is implicated in a variety of peripheral indications. The Company was founded upon the pioneering work of Katerina Akassoglou, Ph.D., Senior Investigator at Gladstone Institutes and Professor of Neurology at the University of California, San Francisco. Dr. Akassoglou and colleagues discovered that fibrin, a blood-clotting factor, is implicated in the toxic inflammation that activates the brain’s immune cell response and damages neurons resulting in loss of brain function in models for Alzheimer’s disease and multiple sclerosis.

Press releases

Therini Bio Raises Additional $39M Series A Financing to Advance Clinical Development of Neurodegenerative Disease Pipeline
May 14, 2025
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Therini Bio Announces Positive Phase 1a Trial Results Evaluating THN391 for Neurodegenerative Diseases
May 05, 2025
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Therini Bio Announces Interim Results from the Phase 1 Trial of THN391 for the Potential Treatment of Dementia
Oct 24, 2023
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Therini Bio Initiates First-In-Human Dosing in Phase 1 Trial of THN391, a Novel Fibrin-Targeting Therapy for Alzheimer’s Disease
May 15, 2023
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Therini Bio Raises $36M Series A Financing to Develop Fibrin-Targeted Therapies for Neurodegenerative and Retinal Diseases
Apr 27, 2023
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Therini Bio Secures $17 Million Investment to Advance Fibrin Therapeutic Candidates Towards the Clinic
May 10, 2021
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Tisento Therapeutics
Private
Cambridge, MA
www.tisentotx.com
Developing Zagociguat, a first and best-in-class oral, once-daily investigational medicine for the treatment of mitochondrial diseases, beginning with MELAS (mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes).

Tisento Therapeutics is a biotechnology company developing Zagociguat, a brain-penetrant sGC stimulator that is hypothesized to rebalance the dysregulated cellular pathways in MELAS and thus address a myriad of MELAS symptoms, including cognitive impairment and fatigue. Zagociguat demonstrated improvements across key domains of MELAS pathophysiology in a Phase 2a study and is currently in a Phase 2b study.

Press releases

First Participant Dosed in Tisento Therapeutics’ Global Phase 2b PRIZM Study Evaluating Zagociguat for the Treatment of MELAS
Feb 04, 2025
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Ultragenyx
Public
www.ultragenyx.com
Committed to bringing to market life-transforming therapeutics.

Ultragenyx is a public, clinical-stage biotechnology company committed to bringing to market life-transforming therapeutics for patients with rare and ultra-rare metabolic genetic diseases. Founded in 2010, the company is rapidly building a diverse portfolio of product candidates with the potential to address diseases for which the unmet medical need is high, the biology for treatment is clear, and for which there are no effective treatments.

The company is led by a management team experienced in the development and commercialization of rare disease therapeutics. Ultragenyx’s strategy is predicated upon time and cost-efficient drug development, with the goal of delivering safe and effective therapies to patients with the utmost urgency.

Press releases

Ultragenyx Announces Intent to File for Conditional Approval in Europe for Sialic Acid Extended-Release Tablets in Hereditary Inclusion Body Myopathy
Jan 12, 2015
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Ultragenyx Announces License of Intellectual Property Related to the Treatment of Huntington's Disease With Triheptanoin
Jan 07, 2015
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Ultragenyx Announces Initiation of Phase 3 Study of Recombinant Human Beta- Glucuronidase in Mucopolysaccharidosis Type 7
Dec 15, 2014
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Ultragenyx Announces Interim Data From Phase 2 Extension Study of Sialic Acid Extended- Release at International Congress of the World Muscle Society
Oct 13, 2014
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Ultragenyx Announces Positive Results From a Long-Term Phase 1/2 Study of KRN23 in Adult Patients With X-Linked Hypophosphatemia
Sep 15, 2014
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Ultragenyx Announces Positive Interim Data From Phase 1/2 Study of Recombinant Human Beta-Glucuronidase in Mucopolysaccharidosis 7
Sep 03, 2014
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Ultragenyx Announces License of Intellectual Property for the Treatment of Epilepsy and Other Seizure-Related Disorders With Triheptanoin
Aug 05, 2014
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Ultragenyx Announces Closing of Public Offering of Common Stock and Exercise of Underwriters' Option to Purchase Additional Shares
Jul 14, 2014
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Ultragenyx Announces Pricing of Public Offering of Common Stock
Jul 09, 2014
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Ultragenyx Announces Initiation of a Phase 2 Study of KRN23 for Pediatric X-Linked Hypophosphatemia in the US and EU
Jul 01, 2014
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Ultragenyx Announces Results From Phase 1/2 Study of KRN23 in X-linked Hypophosphatemia in Adults
Jun 24, 2014
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Ultragenyx Announces Positive Data From Phase 2 Study of Sialic Acid Extended-Release at Emerging Sciences Session of American Academy of Neurology Annual Meeting
Apr 30, 2014
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Ultragenyx Announces Preliminary Data From Phase 1/2 Study of Recombinant Human Beta-Glucuronidase in Mucopolysaccharidosis 7
Mar 27, 2014
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Ultragenyx Reports Fourth Quarter and Full Year 2013 Financial Results
Mar 24, 2014
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Ultragenyx Announces First Patient Enrolled in Phase 2 Study of Triheptanoin in Glucose Transporter Type-1 Deficiency Syndrome
Mar 11, 2014
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Ultragenyx Announces Initiation of Phase 2 Study for Patients with Long-Chain Fatty Acid Oxidation Disorders
Feb 11, 2014
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Ultragenyx Appoints Clay Siegall, Ph.D. and Matthew Fust to Board of Directors
Feb 06, 2014
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Ultragenyx Announces Pricing of Initial Public Offering
Jan 30, 2014
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Ultragenyx Announces Results from Phase 2 Study of Sialic Acid Extended-Release Treatment in Hereditary Inclusion Body Myopathy
Dec 20, 2013
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Ultragenyx Announces Initiation of Phase 1/2 Study of Recombinant Human Beta-Glucuronidase (rhGUS) in Mucopolysaccharidosis Type 7 (MPS 7)
Dec 04, 2013
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Ultragenyx Raises $75 Million in Oversubscribed Crossover Financing
Dec 19, 2012
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Unum Therapeutics
Public
www.unumrx.com
Using proprietary T-cell engineering technology in combination with tumor-targeting antibodies.

Unum Therapeutics uses proprietary T-cell engineering technology in combination with tumor-targeting antibodies to activate the body's own immune system to fight cancer. Unum's lead program, based on its Antibody-Coupled T-cell Receptor (ACTR) technology, is in clinical testing to assess safety and efficacy.

"It's wonderful to have SV as a key part of the series A financing for Unum. Bernard and his team have established a strong track record of building great companies with the potential to really change the practice of medicine. Their strategic focus and knowledge of what Pharma values will be valuable assets for Unum"

Charles Wilson
President & CEO, Unum Therapeutics

Press releases

Unum Therapeutics Announces Abstract Accepted for Presentation at the Fourth CRI-CIMTEATI- AACR International Cancer Immunotherapy Conference
Sep 17, 2018
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Unum Therapeutics Announces Active Investigational New Drug (IND) Application for Antibody-Coupled T Cell Receptor (ACTR) platform in Combination with Trastuzumab in Patients with HER2+ Advanced Cancers
Aug 13, 2018
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Unum Therapeutics Joins Russell 3000® Index
Jun 25, 2018
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Unum Therapeutics Announces Closing of Initial Public Offering and Concurrent Private Placement with Seattle Genetics
Apr 03, 2018
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Unum Therapeutics Moves to New Headquarters in Cambridge, MA as It Continues to Expand and Advance its Cellular Immunotherapy Pipeline
Jan 26, 2016
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Unum Therapeutics Expands Leadership Team by Appointing Dr. Michael J. Vasconcelles as Chief Medical Officer
Oct 21, 2015
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FierceBiotech names Unum Therapeutics as one of its “Fierce 15” Biotech Companies of 2015
Sep 30, 2015
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Unum Therapeutics Announces $65 Million Series B Financing Round
Jun 11, 2015
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Seattle Genetics and Unum Therapeutics Enter into Strategic Cancer Immunotherapy Collaboration
Jun 08, 2015
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Fidelity Biosciences and Atlas Venture Lead $12 Million Series A Funding to Launch Unum Therapeutics, a New Cellular Immunotherapy Company
Oct 21, 2014
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Veralox Therapeutics Inc
Private
Frederik, MD
veralox.com
Developing first-in-class therapeutics targeting 12-Lipoxygenase.

Veralox Therapeutics Inc is developing first-in-class therapeutics targeting 12-Lipoxygenase (12-LOX) to bring new treatments to patients with rare blood disorders and diabetes. Through the 12-LOX pathway, Veralox’s approach targets a novel mechanism of the underlying disease pathologies. The company is advancing lead programs in heparin-induced thrombocytopenia (HIT), HIT with thrombosis (HITT) and type 1 diabetes (T1D). Veralox is committed and focused on developing better therapies to address these unmet medical needs.

Press releases

Veralox Names Jonathan Mow as Chief Executive Officer as the Company Advances Development of First-in-Class Therapies for Immune-Mediated Diseases in Conjunction with Financing
Jun 20, 2023
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Veralox Therapeutics announces closing of $16.6 Million series A financing and announces new board members
Jun 16, 2021
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Veralox Therapeutics Raises $5.4 Million in Seed Funding Co-Led by JDRF T1D Fund and Sanofi Ventures
Sep 05, 2019
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Voluntis
Public
www.voluntis.com
Creating digital therapeutics that empower people suffering from chronic conditions to self-manage their treatment.

Voluntis creates digital therapeutics that empower people suffering from chronic conditions to self-manage their treatment every day, thus improving real-world outcomes. Combining mobile and web apps, Voluntis’ solutions deliver personalized recommendations to the patient and the care team so that they can, for example, adjust treatment dosage, manage side effects or monitor symptoms. Its digital therapeutics include Insulia® and Diabeo® in diabetes in partnership with Sanofi and Onduo, as well as eCO, with AstraZeneca, and ZEMY, with Roche, in oncology.

"We are delighted to extend our long-standing business partnership with Sanofi through the participation of Sanofi Ventures in our IPO. This investment will help support our ambitious growth strategy with regards to our digital therapeutics portfolio in diabetes and oncology."

Pierre Leurent
CEO and co-founder, VOLUNTIS

Yumanity Therapeutics
Public
www.yumanity.com
Transforming drug discovery for neurodegenerative diseases caused by protein misfolding.

Yumanity Therapeutics is transforming drug discovery for neurodegenerative diseases caused by protein misfolding. Formed in 2014 by renowned biotech industry leader, Tony Coles, M.D., and protein folding science pioneer, Susan Lindquist, Ph.D., the company is initially focused on discovering disease-modifying therapies for patients with Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis (ALS). Leveraging its three integrated platforms, Yumanity’s innovative new approach to drug discovery and development concentrates on reversing the cellular phenotypes and disease pathologies caused by protein misfolding.

Press releases

Yumanity Therapeutics Initiates Phase 1 Clinical Trial of Lead Candidate YTX-7739 for the Treatment of Parkinson’s Disease
Oct 07, 2019
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Yumanity Therapeutics and the New York Stem Cell Foundation Research Institute Announce Discovery Collaboration
Jun 22, 2016
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Yumanity Therapeutics Closes $45 Million Series A Financing
Feb 10, 2016
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