PRIVATE

Fulcrum Therapeutics is a biotechnology company developing new medicines to deliver a new future to patients and their families by transforming gene regulation in disease. Fulcrum's therapies are based on modulating gene regulation via control of genetic on and off switches of disease genes. Fulcrum, headquartered in Cambridge, Mass., was launched by Third Rock Ventures in 2016 and named a "Fierce 15" company later that year.

"We are excited to be partnering with Sanofi Ventures. Their combination of strategic investment in early-stage companies with transformative technologies of strategic interest to Sanofi and rapid decision making with direct access to senior executives is consistent with an agile small company mindset."

Robert J. Gould, Ph.D.
President and C.E.O., Fulcrum Therapeutics

www.fulcrumtx.com

PRIVATE

Click Therapeutics, Inc. develops and commercializes software as prescription medical treatments for people with unmet medical needs. Through cognitive and neurobehavioral mechanisms, Click’s Digital Therapeutics™ enable change within individuals, and are designed to be used independently or in conjunction with biomedical treatments. The Clickometrics® adaptive data science platform continuously personalizes user experience to optimize engagement and outcomes. Following a groundbreaking clinical trial, Click’s industry-leading smoking cessation program is available nationwide through a wide variety of payers, providers, and employers. Click’s lead prescription program is entering into a multi-center, randomized, controlled, parallel-group, phase III FDA registration trial for the treatment of Major Depressive Disorder in adults.

clicktherapeutics.com

PUBLIC

Voluntis creates digital therapeutics that empower people suffering from chronic conditions to self-manage their treatment every day, thus improving real-world outcomes. Combining mobile and web apps, Voluntis’ solutions deliver personalized recommendations to the patient and the care team so that they can, for example, adjust treatment dosage, manage side effects or monitor symptoms. Its digital therapeutics include Insulia® and Diabeo® in diabetes in partnership with Sanofi and Onduo, as well as eCO, with AstraZeneca, and ZEMY, with Roche, in oncology.

"We are delighted to extend our long-standing business partnership with Sanofi through the participation of Sanofi Ventures in our IPO. This investment will help support our ambitious growth strategy with regards to our digital therapeutics portfolio in diabetes and oncology."

Pierre Leurent
CEO and co-founder, VOLUNTIS

www.voluntis.com

PRIVATE

Expansion Therapeutics is a drug discovery and development company pursuing the vast potential of small molecule medicines for RNA-mediated diseases. Based on exclusive worldwide rights to groundbreaking research from the laboratory of Matthew D. Disney, Ph.D., at The Scripps Research Institute, Expansion has assembled the intellectual property, know-how, and proprietary enabling technologies and tools necessary to facilitate the creation of potent and specific small molecule binders of RNA. Through this unique platform, Expansion is building a portfolio of novel RNA-targeted drug candidates with activity across a broad number of disease indications. The company’s initial development focus is on therapies for patients with expansion repeat diseases who currently have limited and unsatisfactory treatment options. Expansion is based in San Diego, California and Jupiter, Florida.

www.expansionrx.com 

PRIVATE

Curisium is a healthcare technology and services company that provides scalable innovative contracting solutions with its blockchain-based platform. The Curisium platform uses cutting-edge blockchain and secure computation technologies to allow payers, providers, and life science companies to efficiently and securely engage in innovative, patient-centric value-based contracts.

www.curisium.com 

PRIVATE

Inozyme Pharma is a biotechnology company developing new medicines to treat rare disorders of calcification. These diseases are characterized by mineral imbalances, which lead to over calcification of soft tissues and under mineralization of bone. Founded in 2016 with technology licensed from Yale University, the company possesses a deep understanding of the biology of calcification which it is using to develop new medicines that have the potential to drastically improve the standard-of-care and change treatment paradigms. Inozyme’s lead candidate is an enzyme replacement therapy designed to treat calcification disorders of the circulatory system, bone and kidney for which insufficient treatment options currently exist.

www.inozyme.com

PRIVATE

Omada Health is a digital behavioral medicine company that inspires and enables people to change the habits that put them most at risk for chronic conditions like heart disease and type 2 diabetes. The company is the largest CDC-recognized provider of the National Diabetes Prevention Program, and since its founding, has enrolled more than 100,000 participants. Omada’s program combines proven behavioral science, the power of professional health coaches and peer groups, connected technology, and world-class design to deliver clinically-meaningful results.

www.omadahealth.com 

 

PRIVATE

Rooted in rigorous science, Evidation captures and analyzes passive, continuous behavior data to quantify health outcomes that more accurately reflect an individual's day-to-day experience.

www.evidation.com 

PRIVATE

Science 37 has created a new clinical trial operating model – the metasite™ – that unlocks access so researchers can find the right patients, and patients can find the right trials. Its Network Oriented Research Assistant, NORA™, is an accelerated patient-centric mobile research platform that connects everyone safely and securely. Science 37 offers end-to-end clinical trial services without geographic limitations, making clinical research faster to accelerate biomedical discovery. Ultimately, Science 37 enables better, faster, people-powered science and brings clinical trials to scale.

"It's clear SV shares our mission of unlocking access to clinical trials and how that fits into the larger digital revolution that uses technology to enable patients to take a more proactive role in their own health. We all share the common goal of bringing new cures to people faster. By working closely with Sanofi, Science 37 will exponentially accelerate clinical research in neurodegenerative diseases and other rare genetic disorders."

Noah Craft
co-founder and CEO, Science37

www.science37.com

PRIVATE

ImmuneXcite is developing transformative immuno-oncology products that utilize the power of both the innate and adaptive immune response. The company is using its mAbXcite technology to leverage the innate immune system to initiate an anti-tumor response, which subsequently primes the natural adaptive immune response to further limit tumor growth and metastasis.

www.immunexcite.com 

PRIVATE

Yumanity Therapeutics is transforming drug discovery for neurodegenerative diseases caused by protein misfolding. Formed in 2014 by renowned biotech industry leader, Tony Coles, M.D., and protein folding science pioneer, Susan Lindquist, Ph.D., the company is initially focused on discovering disease-modifying therapies for patients with Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis (ALS). Leveraging its three integrated platforms, Yumanity’s innovative new approach to drug discovery and development concentrates on reversing the cellular phenotypes and disease pathologies caused by protein misfolding.

"Sanofi Ventures shares Yumanity's vision of following the science where it leads, and we are thrilled to work together in our efforts to bring much needed new therapies to patients living with Alzheimer’s, Parkinson’s and Lou Gehrig’s Diseases, among other debilitating and life threatening neurodegenerative diseases."

Tony Coles, M.D.
Chairman and CEO, Yumanity

www.yumanity.com

 

PRIVATE

NeuroVia, Inc. is a specialty pharmaceutical company focused on the development of therapeutics to treat orphan disease with significant unmet medical need.

www.neurovia-inc.com 

 

PUBLIC

Selecta is developing immune modulating nanomedicines that enable novel biologic therapies by preventing harmful immune responses. Proprietary Synthetic Vaccine Particles (SVP) elicit lasting and antigen-specific tolerance to co-formulated biologic drugs. Selecta is conducting clinical studies to develop the first non-immunogenic biologic therapy to treat severe gout and is focused in the near-term on developing immunotherapeutic candidates that eliminate immune responses to adeno-associated virus (AAV) vectors that would enable a wide range of new applications for gene therapies.

"Sanofi has been a pioneer in recognizing the importance of antigen-specific immune modulation in vaccines, allergies, enzyme replacement therapy and auto-immune diseases. SV is of tremendous help to facilitate our dialogue within Sanofi and an esteemed member of our investor network." 

Werner Cautreels, President & CEO, Selecta Biosciences

www.selectabio.com

PUBLIC

Ovid Therapeutics Inc. is a public, New York based, biopharmaceutical company committed to transforming the lives of patients with rare and orphan diseases of the brain. Ovid focuses on patients and their unmet medical needs. Using the significant operational, product development and business development experience of its management team, Ovid aims to become a leading neurology company, with multiple products and a rich pipeline, coupled with compelling research and development.

www.ovidrx.com

PUBLIC

Unum Therapeutics uses proprietary T-cell engineering technology in combination with tumor-targeting antibodies to activate the body's own immune system to fight cancer. Unum's lead program, based on its Antibody-Coupled T-cell Receptor (ACTR) technology, is in clinical testing to assess safety and efficacy.

"It's wonderful to have SV as a key part of the series A financing for Unum. Bernard and his team have established a strong track record of building great companies with the potential to really change the practice of medicine. Their strategic focus and knowledge of what Pharma values will be valuable assets for Unum"

Charles Wilson
President & CEO, Unum Therapeutics

www.unumrx.com

PRIVATE

Kymera Therapeutics is a biotechnology company pioneering a transformative new approach to treating previously untreatable diseases. The company is advancing the field of targeted protein degradation, accessing the body’s innate protein recycling machinery to degrade dysregulated, disease-causing proteins. Powered by Pegasus™, a game-changing integrated degradation platform, Kymera is accelerating drug discovery with an unmatched ability to target and degrade the most intractable of proteins, and advance new treatment options for patients.

www.kymeratx.com

PRIVATE

Lysosomal Therapeutics Inc. (LTI) is dedicated to innovative small molecule research and development in the field of neurodegeneration, yielding new treatment options for patients with severe neurological diseases. Our strategy leverages the clinically-validated link between lysosome-based genetic disorders and neurodegenerative diseases to establish a unique and effective molecular platform for novel drug discovery. LTI’s lead program targets Gaucher-related neurodegeneration, Parkinson’s disease and other synucleinopathies.

www.lysosomaltx.com

IPO

Immune Design is a public immunotherapy company employing next-generation in vivo approaches to enable the body's immune system to fight disease. The company's technologies are engineered to activate the immune system's natural ability to create tumor-specific cytotoxic T cells to fight cancer and other chronic diseases. Immune Design's clinical programs are the product of its two synergistic discovery platforms: ZVex™ and GLAAS™. Immune Design has offices in Seattle, Washington and South San Francisco, California.

"We are very pleased that SV has decided to invest in Immune Design. Our companies share the vision of harnessing the immune system to discover and develop new immune-based therapies in a number of large human diseases in which both companies are interested."

Carlos Paya
President & CEO, Immune Design

www.immunedesign.com

PRIVATE

Common Sensing is introducing GoCap, a safer and more convenient way for diabetics to track and dose insulin. GoCap empowers patients by reducing the burden of manual logging, while providing helpful safety alerts and reminders. The aim is to connect patients, family, and care providers with better information feedback. By improving care engagement and motivation, GoCap holds the potential to improve quality of life for diabetics and reduce cost burdens for the health care system.

"Sanofi Ventures is not hesitant to reach out into its network to provide hands-on mentorship and development support resources that are invaluable to any early-stage startup."

Richard Whalley
CEO & Co-Founder, Common Sensing

www.common-sensing.com

PRIVATE

Edimer Pharmaceuticals is dedicated to developing EDI200 as a treatment for X-linked Hypohidrotic Ectodermal Dysplasia (XLHED). EDI200 is a recombinant version of ectodysplasin A1 – the molecule that is missing in patients with XLHED. XLHED is a rare orphan disease that causes a range of symptoms including lack of sweat glands, poor temperature control, respiratory problems, and hair and tooth malformations.

Edimer is led by a team of seasoned biotechnology industry veterans with deep experience in drug development complemented by a strong network of world-class clinical and scientific advisors. The company is based in Cambridge, Massachusetts.

"We are excited about working closely with SV as we move our lead product, EDI200, through clinical development. Clearly, their expertise in creating value in the rare disease space is unparalleled in the biopharmaceutical industry and we look forward to leveraging this know-how."

Neil Kirby
President & CEO, Edimer Pharmaceuticals

www.edimerpharma.com

IPO

Ultragenyx is a public, clinical-stage biotechnology company committed to bringing to market life-transforming therapeutics for patients with rare and ultra-rare metabolic genetic diseases. Founded in 2010, the company is rapidly building a diverse portfolio of product candidates with the potential to address diseases for which the unmet medical need is high, the biology for treatment is clear, and for which there are no effective treatments.

The company is led by a management team experienced in the development and commercialization of rare disease therapeutics. Ultragenyx’s strategy is predicated upon time and cost-efficient drug development, with the goal of delivering safe and effective therapies to patients with the utmost urgency.

www.ultragenyx.com

PRIVATE

Kahr is a privately held, clinical stage company pioneering the development of multi-functional fusion-protein drugs with potential applications in oncology and autoimmune diseases.

"Our partnership with SV has been exceptionally productive in ways that exceeds funding per se, especially the valuable development guidance we have obtained from Sanofi R&D."

Noam Shani
CEO, Kahr Medical

www.kahr-medical.com


IPO

Bluebird bio is a public company developing innovative gene therapies for severe genetic and orphan diseases. At the heart of bluebird bio's product creation efforts is its broadly applicable gene therapy platform for the development of novel treatments for diseases with few or no clinical options. The company's novel approach uses stem cells harvested from the patient's bone marrow into which a healthy version of the disease causing gene is inserted. After being grown in culture, those cells are given back to the patient. bluebird bio's approach represents a true paradigm shift in the treatment of severe genetic diseases by eliminating the potential complications associated with donor cell transplantation and potentially presenting a one-time transformative therapy. Bluebird bio has two later stage clinical products in development for childhood cerebral adrenoleukodystrophy (CCALD) and beta-thalassemia/sickle cell anemia. The company is also applying its gene therapy platform to oncology through the development of chimeric antigen receptor T-cells in collaboration with Baylor University and Celgene.

www.bluebirdbio.com

PUBLIC

GlycoMimetics is a public, clinical stage biotechnology company focused on the discovery and development of novel glycomimetic drugs to address unmet medical needs resulting from diseases in which carbohydrate biology plays a key role. Using its expertise in carbohydrate chemistry and knowledge of carbohydrate biology, the company is developing a pipeline of glycomimetic drug candidates that inhibit disease-related functions of carbohydrates, such as the roles they play in inflammation, cancer and infection.

"GlycoMimetics has enjoyed a very positive and productive relationship with SV. We have appreciated the opportunity to consult with functional area experts as well as to be in regular communication about the progress of our unpartnered programs. It’s great to have a chance to be ‘on the radar screen'."

Rachel K. King
CEO, GlycoMimetics

www.glycomimetics.com

IPO

Fate Therapeutics is a clinical-stage biopharmaceutical company dedicated to the development of next-generation cellular immunotherapies for cancer and immune disorders. The Company’s first-in-class cell therapy products undergoing clinical development today utilize healthy donor cells, which are modified ex vivo using pharmacologic modulators, such as small molecules, to improve the cells’ biological properties and therapeutic function. The company is pioneering a revolutionary approach to cell therapy using renewable master induced pluripotent stem cell (iPSC) lines generated from a proprietary iPSC product platform to derive cell therapy products that can be delivered off-the-shelf for the treatment of a large number of patients. Fate Therapeutics is a public company headquartered in San Diego, CA, with a subsidiary in Ottawa, Canada.

www.fatetherapeutics.com

IPO

Prior to its relaunch as Humanigen, Inc., KaloBios was a public biopharmaceutical company focused on the development of monoclonal antibody therapeutics to treat serious medical conditions with a primary clinical focus on severe respiratory diseases and cancer.

www.kalobios.com

IPO

Proteostasis Therapeutics, Inc. (PTI) is developing disease-modifying therapeutics for diseases of protein processing. Using the DRT™ platform, a phenotypic screening approach based on the use of functionally pertinent cellular assays and disease relevant models, PTI identifies highly selective drug candidates that modulate the proteostasis imbalance in the cell. PTI's lead program is focused on treating cystic fibrosis. 

www.proteostasis.com

 

IPO

MacroGenics is a clinical-stage biopharmaceutical company focused on discovering and developing innovative monoclonal antibody-based therapeutics for the treatment of cancer and autoimmune diseases. The company generates its pipeline of product candidates from its proprietary suite of next-generation antibody technology platforms, which it believes improve the performance of monoclonal antibodies and antibody-derived molecules. The company creates both differentiated molecules that are directed to novel cancer targets, as well as "bio-betters," which are drugs designed to improve upon marketed medicines. The combination of MacroGenics' technology platforms and antibody engineering expertise has allowed the company to generate promising product candidates and enter into several strategic collaborations with global pharmaceutical and biotechnology companies.

www.macrogenics.com

 

TRADE SALE

Lumena Pharmaceuticals, acquired by Shire plc in June 2014, is a biopharmaceutical company dedicated to providing better treatment options for adults and children who suffer from rare and debilitating liver diseases and serious metabolic disorders. The company is focused on developing oral therapeutics to improve liver function, relieve disease symptoms and dramatically benefit patient health.